Pajjiż: Stati Uniti
Lingwa: Ingliż
Sors: NLM (National Library of Medicine)
CLONIDINE HYDROCHLORIDE (UNII: W76I6XXF06) (CLONIDINE - UNII:MN3L5RMN02)
A-S Medication Solutions
CLONIDINE HYDROCHLORIDE
CLONIDINE HYDROCHLORIDE 0.1 mg
ORAL
PRESCRIPTION DRUG
Clonidine hydrochloride tablets, USP are indicated in the treatment of hypertension. Clonidine hydrochloride tablets, USP may be employed alone or concomitantly with other antihypertensive agents. Clonidine hydrochloride tablets should not be used in patients with known hypersensitivity to clonidine (see PRECAUTIONS ).
Product: 50090-0135 NDC: 50090-0135-0 30 TABLET in a BOTTLE NDC: 50090-0135-1 60 TABLET in a BOTTLE NDC: 50090-0135-2 100 TABLET in a BOTTLE NDC: 50090-0135-7 90 TABLET in a BOTTLE NDC: 50090-0135-8 180 TABLET in a BOTTLE Product: 50090-2531 NDC: 50090-2531-1 60 TABLET in a BOTTLE Product: 50090-2600 NDC: 50090-2600-0 30 TABLET in a BOTTLE NDC: 50090-2600-1 60 TABLET in a BOTTLE NDC: 50090-2600-5 180 TABLET in a BOTTLE NDC: 50090-2600-6 90 TABLET in a BOTTLE
Abbreviated New Drug Application
CLONIDINE HYDROCHLORIDE- CLONIDINE HYDROCHLORIDE TABLET A-S MEDICATION SOLUTIONS ---------- CLONIDINE HYDROCHLORIDE TABLETS, USP Oral Antihypertensive Tablets of 0.1 mg, 0.2 mg and 0.3 mg RX ONLY PRESCRIBING INFORMATION DESCRIPTION Clonidine hydrochloride, USP is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg and 0.3 mg. The 0.1 mg tablet is equivalent to 0.087 mg of the free base. The inactive ingredients are colloidal silicon dioxide, corn starch, calcium phosphate dibasic, hydroxypropyl cellulose, microcrystalline cellulose, lactose monohydrate and magnesium stearate. In addition, the 0.1 mg tablets contain FD&C Red No. 40, and the 0.2 mg and 0.3 mg tablets contain FD&C Yellow No. 6 as color additives respectively. Clonidine hydrochloride is an imidazoline derivative and exists as a mesomeric compound. The chemical name is 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride. The following is the structural formula: Clonidine hydrochloride is an odorless, bitter, white, crystalline substance soluble in water and alcohol. CLINICAL PHARMACOLOGY Clonidine stimulates alpha-adrenoreceptors in the brain stem. This action results in reduced sympathetic outflow from the central nervous system and in decreases in peripheral resistance, renal vascular resistance, heart rate, and blood pressure. Clonidine hydrochloride tablets act relatively rapidly. The patient's blood pressure declines within 30 to 60 minutes after an oral dose, the maximum decrease occurring within 2 to 4 hours. Renal blood flow and glomerular filtration rate remain essentially unchanged. Normal postural reflexes are intact; therefore, orthostatic symptoms are mild and infrequent. Acute studies with clonidine hydrochloride in humans have demonstrated a moderate reduction (15% to 20%) of cardiac output in the supine position with no change in the peripheral resistance: at a 45° tilt there is a smaller reduction in cardiac output and a decrease of peripheral r Aqra d-dokument sħiħ