Pajjiż: Malasja
Lingwa: Ingliż
Sors: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
HYDROCHLOROTHIAZIDE; LOSARTAN POTASSIUM
ORGANON MALAYSIA SDN. BHD.
HYDROCHLOROTHIAZIDE; LOSARTAN POTASSIUM
30 Tablet Tablets
Organon Pharma (UK) Limited
_Consumer Medication Information Leaflet (RiMUP) _ 1 HYZAAR ® /FORTZAAR ® Losartan Potassium/Hydrochlorothiazide (50mg/12.5mg, 100mg/12.5mg, 100mg/25mg) Copyright 2022 Organon group of companies. All rights reserved. WHAT IS IN THIS LEAFLET 1. What _HYZAAR/FORTZAAR _ is used for 2. How _HYZAAR/FORTZAAR_ works 3. Before you take _HYZAAR/FORTZAAR _ _4._ _ _ How to take _ _ _HYZAAR/FORTZAAR _ _5._ _ _ While you are taking _ _ _HYZAAR/FORTZAAR _ 6. Side effects 7. Storage and disposal of _HYZAAR/FORTZAAR _ 8. Product description 9. Product Manufacturer and Product Registration Holder 10. Date of Revision WHAT _HYZAAR/FORTZAAR _IS USED FOR _HYZAAR/FORTZAAR _ is a combination of an angiotensin II receptor antagonist (losartan) and a diuretic (hydrochlorothiazide). Losartan and hydrochlorothiazide work together to lower high blood pressure. If you have high blood pressure and a thickening of the left ventricle, the heart’s main pumping chamber, your doctor has prescribed _HYZAAR/FORTZAAR _ to help lower the risk of cardiovascular events, such as stroke. HOW _HYZAAR/FORTZAAR _ WORKS The losartan ingredient of _HYZAAR/FORZAAR _ lowers blood pressure by specifically blocking a substance called angiotensin II. Angiotensin II normally tightens your blood vessels. The losartan ingredient of _HYZAAR/FORTZAAR _ allows them to relax. The hydrochlorothiazide ingredient of _HYZAAR/FORTZAAR _ works by making your kidneys pass more water and salt. Together, losartan and hydrochlorothiazide lower high blood pressure. Although your doctor will be able to tell you that the medicine is working by measuring your blood pressure, you probably will feel no different while you are taking _HYZAAR/FORTZAAR. _ _ _ WHY HAS MY DOCTOR PRESCRIBED _HYZAAR/FORTZAAR_? Your doctor has prescribed _HYZAAR/FORTZAAR _ because you have a condition known as hypertension or high blood pressure. In patients with high blood pressure and a thickening of the left ventricle, losartan, often in combination with hydrochlorothiazide, reduces the risk of stroke an Aqra d-dokument sħiħ
I. THERAPEUTIC CLASS II. INDICATIONS III. CLINICAL PHARMACOLOGY LOCAL PRODUCT CIRCULAR LPC-OG0954A-T-032022-MALAYSIA TABLETS HYZAAR/FORTZAAR ® (losartan potassium and hydrochlorothiazide) HYZAAR/FORTZAAR ® (losartan potassium and hydrochlorothiazide) is the first combination of an angiotensin II receptor (type AT 1 ) antagonist and a diuretic. HYPERTENSION HYZAAR/FORTZAAR is indicated for the treatment of hypertension, for patients in whom combination therapy is appropriate. HYPERTENSIVE PATIENTS WITH LEFT VENTRICULAR HYPERTROPHY HYZAAR/FORTZAAR is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, but there is evidence that this benefit does not apply to BLACK patients. (See PRECAUTIONS, _Race, _CLINICAL PHARMACOLOGY, _Pharmacodynamics and Clinical Effects, Losartan Potassium, Reduction in the Risk of _ _Stroke, Race _and DOSAGE AND ADMINISTRATION.) MECHANISM OF ACTION Losartan-Hydrochlorothiazide The components of HYZAAR/FORTZAAR have been shown to have an additive effect on blood pressure reduction, reducing blood pressure to a greater degree than either component alone. This effect is thought to be a result of the complimentary actions of both components. Further, as a result of its diuretic effect, hydrochlorothiazide increases plasma renin activity, increases aldosterone secretion, decreases serum potassium, and increases the levels of angiotensin II. Administration of losartan blocks all the physiologically relevant actions of angiotensin II and through inhibition of aldosterone could tend to attenuate the potassium loss associated with the diuretic. Losartan has been shown to have a mild and transient uricosuric effect. Hydrochlorothiazide has been shown to cause modest increases in uric acid; the combination of losartan and hydrochlorothiazide tends to attenuate the diuretic-induced hyperuricemia. PHARMACOKINETICS _ABSORPTION _ _ _ Losartan Following oral administration, losartan is well absorbed and undergoes first-pass metabolism, forming an active Aqra d-dokument sħiħ