Land: Verenigde Staten
Taal: Engels
Bron: NLM (National Library of Medicine)
carprofen (UNII: FFL0D546HO) (carprofen - UNII:FFL0D546HO)
BUTLER ANIMAL HEALTH SUPPLY, LLC dba COVETRUS NORTH AMERICA
SUBCUTANEOUS
PRESCRIPTION
Carprofen injection is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. Carprofen should not be used in dogs exhibiting previous hypersensitivity to carprofen.
Carprofen injection is supplied in 20 mL and 50 mL, amber, glass, sterile, multi-dose vials.
Abbreviated New Animal Drug Application
CARPROFEN- CARPROFEN INJECTION, SOLUTION BUTLER ANIMAL HEALTH SUPPLY, LLC DBA COVETRUS NORTH AMERICA ---------- COVETRUS Approved by FDA under ANADA # 200-520 CARPROFEN INJECTION STERILE INJECTABLE SOLUTION 50 MG/ML NON-STEROIDAL ANTI-INFLAMMATORY DRUG FOR SUBCUTANEOUS USE IN DOGS ONLY CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: Carprofen injection is a sterile solution containing carprofen, a non-steroidal anti- inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen, and ketoprofen. Carprofen is the non-proprietary designation for a substituted carbazole, 6-chloro-α- methyl-9H-carbazole-2-acetic acid. The empirical formula is C H ClNO and the molecular weight 273.72. The chemical structure of carprofen is: Each mL of Carprofen injection contains 50.0 mg carprofen, 30.0 mg arginine, 88.5 mg glycocholic acid, 169.0 mg lecithin, 10.0 mg benzyl alcohol, 6.17 mg sodium hydroxide, with additional sodium hydroxide and hydrochloric acid as needed to adjust pH, and water for injection. CLINICAL PHARMACOLOGY: Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent with characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models. The mechanism of action of carprofen, like that of other NSAlDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. ® 15 12 2 1 2 The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity. The specificity of a particular NSAID for COX-2 versus COX-1 may vary from species to species. In an _in vitro_ study using canine cell cultures, carprofen demonstrated sel Lees het volledige document