Land: Verenigde Staten
Taal: Engels
Bron: NLM (National Library of Medicine)
PRAZIQUANTEL (UNII: 6490C9U457) (PRAZIQUANTEL - UNII:6490C9U457), PYRANTEL PAMOATE (UNII: 81BK194Z5M) (PYRANTEL - UNII:4QIH0N49E7), FEBANTEL (UNII: S75C401OS1) (FEBANTEL - UNII:S75C401OS1)
Elanco US Inc.
ORAL
PRESCRIPTION
Drontal Plus (praziquantel/pyrantel pamoate/ febantel) Broad Spectrum Anthelmintic Tablets are indicated for removal of Tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus, and removal and control of Echincoccus multilocularis). For removal of Hookworms (Ancylostoma caninum, Uncinaria stenocephala), Ascarids (Toxocara canis, Toxascaris leonina), and Whipworms (Trichuris vulpis) in dogs. DO NOT USE IN PREGNANT ANIMALS. Dogs treated with elevated levels (6 consecutive days with 3 times the labeled dosage rate) of the combination of febantel and praziquantel in early pregnancy demonstrated an increased incidence of abortion and fetal abnormalities.8 The effects of Drontal Plus on pregnant animals have not been determined. There are no known contraindications against the use of praziquantel or pyrantel pamoate in dogs.
Each tablet size is available in bottles of 50 (puppies and small dogs, medium sized dogs) or 30 (large dogs). 50 Tablets/Bottle (Puppies and Small Dogs) 50 Tablets/Bottle (Medium Sized Dogs) 30 Tablets/Bottle (Large Dogs)
New Animal Drug Application
DRONTAL PLUS- PRAZIQUANTEL, PYRANTEL PAMOATE, FEBANTEL TABLET ELANCO US INC. ---------- _ELANCO_™ DRONTAL PLUS (PRAZIQUANTEL/PYRANTEL PAMOATE/FEBANTEL) TABLETS BROAD SPECTRUM ANTHELMINTIC FOR DOGS CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: Drontal Plus (praziquantel/pyrantel pamoate/ febantel) Broad Spectrum Anthelmintic Tablets are available in three sizes. Each size is scored for convenient oral administration. Each Drontal Plus Tablet for Puppies and Small Dogs contains 22.7 mg praziquantel, 22.7 mg pyrantel base as pyrantel pamoate and 113.4 mg febantel. Each Drontal Plus Tablet for Medium Sized Dogs contains 68.0 mg praziquantel, 68.0 mg pyrantel base as pyrantel pamoate and 340.2 mg febantel. Each Drontal Plus Tablet for Large Dogs contains 136.0 mg praziquantel, 136.0 mg pyrantel base as pyrantel pamoate, and 680.4 mg febantel. ACTION: Drontal Plus Tablets contain three active ingredients having different modes of action and spectra of activity. Praziquantel is active against cestodes (tapeworms). Praziquantel is absorbed, metabolized in the liver and excreted in the bile. Upon entering the digestive tract from the bile, cestocidal activity is exhibited. Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. Because of this, whole tapeworms, including the scolices, are very rarely passed after administration of praziquantel. In many instances only disintegrated and partially digested pieces of tapeworms will be seen in the stool. The majority of tapeworms are digested and are not found in the feces. Pyrantel pamoate is active against hookworms and ascarids. Pyrantel pamoate acts on the cholinergic receptors of the nematode resulting in spastic paralysis. Peristaltic action of the intestinal tract then eliminates the parasite. Febantel is active against nematode parasites including whipworms. Febantel is rapidly absorbed and metabolized in the animal. Available information sugge Lees het volledige document