Land: Verenigde Staten
Taal: Engels
Bron: NLM (National Library of Medicine)
eprinomectin (UNII: 75KP30FD8O) (eprinomectin - UNII:75KP30FD8O)
Norbrook Laboratories Limited
TOPICAL
OTC
Eprizero (eprinomectin) Pour-On is indicated for the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi ), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle. Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight, Eprizero Pour-On is indicated for the effective treatment and control of the following parasites. Gastrointestinal Roundworms Lungworms Cattle Grubs (all parasitic stages) Hypoderma lineatum, Hypoderma bovis Lice Damalinia bovis, Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus Mange Mites Chorioptes bovis, Sarcoptes scabiei Horn Flies Haematobia irritans Eprizero (eprinomectin) Pour-On for Beef and Dairy Cattle has been proved to effectively control infections and to protect cattle from re-infection with Dictyocaulus viviparus for 21 days
Eprizero (eprinomectin) Pour-On for Beef and Dairy Cattle is available in a 1 L/33.8 fl oz container with a measure-squeeze-pour system, or in a 2.5 L/84.5 fl oz or 5 L/169 fl oz container or 20 L/676 fl oz container intended for use with appropriate automatic dosing equipment. Made in the UK. Manufactured by: Norbrook Laboratories Limited Newry, BT35 6PU, Co. Down, Northern Ireland. ® Eprizero is a registered trademark of Norbrook Laboratories Limited. Rev. October 2020 121670I04 Norbrook ®
Abbreviated New Animal Drug Application
EPRIZERO- EPRINOMECTIN SOLUTION NORBROOK LABORATORIES LIMITED ---------- Approved by FDA under ANADA # 200-563 EPRIZERO (EPRINOMECTIN) POUR-ON for Beef and Dairy Cattle PARASITICIDE Contains 5 mg eprinomectin/mL NOT FOR USE IN CALVES TO BE PROCESSED FOR VEAL. INTRODUCTION Eprizero Pour-On delivers effective internal and external parasite control in one application. Eprizero Pour-On contains eprinomectin, a unique avermectin. Its broad- spectrum efficacy in a weatherproof formulation, margin of safety, zero slaughter withdrawal and zero milk discard, make it a convenient product for parasite control in beef and dairy cattle, including lactating dairy cattle. MODE OF ACTION Eprinomectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier. INDICATIONS Eprizero (eprinomectin) Pour-On is indicated for the treatment and control of gastrointestinal roundworms (including inhibited _Ostertagia ostertagi_), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle. Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weig Lees het volledige document