Land: Armenië
Taal: Engels
Bron: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում
tretinoin
Arpimed LLC
tretinoin
0,5mg/g
cream
OTC
SUMMARY PRODUCT CHARACTERISTIC (SPC) SILKADERM 0.05% CREAM TRADE NAME – Silkaderm INTERNATIONAL NON-PROPERTY NAME – Tretinoin DOSAGE FORM – Cream for topical use COMPOSITION EACH GRAM OF SILKADERM 0.05% CREAM CONTAINS: _ACTIVE INGREDIENT: _tretinoin - 0.5 mg; _INACTIVE _ _INGREDIENTS: _ glyceryl stearate SE, cetearete 12, cetearete 20, liquid parafin, glycerin, cetostearyl alcohol, methylparaben, propylparaben, diazolidinyl urea, disodium edetate, butyl hydroxy toluene, propylene glycol, dimethicone, water purified. PHARMACOLOGICAL GROUP AND ATC CODE Dermatological drug, retinoid; D10AD01. PHARMACOLOGY Tretinoin is a retinoid and is the acid form of vitamin A. Tretinoin is used primarily in the topical treatment of ACNE VULGARIS when comedones, papules, and pustules predominate. It appears to stimulate mitosis and turnover of follicular epithelial cells and reduce their cohesiveness thereby facilitating the extrusion of existing comedones and preventing the formation of new ones. It also appears to have a thinning effect on the stratum corneum. PHARMACOKINETICS Absorption does not seem to occur to any great extent with topical use. Tretinoin is the only metabolite of retinol, which is normally present in plasma USES SILKADERM is used primarily in the topical treatment of ACNE VULGARIS (both as monotherapy and in combination therapy). ADMINISTRATION_ _ SILKADERM is applied topically to the skin. Patients should be instructed carefully in proper use of the drug, including associated precautions. The skin should be cleansed to remove excessive oiliness and dried 15 to 30 minutes before applying tretinoin lightly, once or twice daily according to response and irritation; some patients may require less frequent applications. Other topical preparations (including skin moisturisers) should not be applied at the same time as tretinoin is applied, and caution is required if other local irritants are used concurrently. There may be apparent exacerbations of the acne during early treatment and a therapeutic response m Lees het volledige document