Land: USA
Språk: engelsk
Kilde: NLM (National Library of Medicine)
ISOFLURANE (UNII: CYS9AKD70P) (ISOFLURANE - UNII:CYS9AKD70P)
Clipper Distributing Company LLC
ISOFLURANE
ISOFLURANE 1 mL in 1 mL
RESPIRATORY (INHALATION)
PRESCRIPTION
Isoflurane, USP is used for induction and maintenance of general anesthesia in horses and dogs. Isoflurane, USP is contraindicated in horses and dogs with known sensitivity to isoflurane or to other halogenated agents.
Isoflurane, USP is packaged in 100 mL and 250 mL amber-colored bottles. 100 ml - NDC 57319-507-05 250 ml - NDC 57319-507-06 Storage: Store at controlled room temperature 15° to 30°C (59° to 86°F). References: 1. Steffey, E.P., Howland, D. Jr., Giri, S. and Eger, E.l. II.: Enflurane, Halothane and Isoflurane Potency in Horses. Am. J. Vet. Res. 38(7): 1037-1039, 1977. 2. Auer, J.A., Garner, H.E., Amend, J.F., Hutcheson, D.P. and Salem, C.A.: Recovery from Anesthesia in Ponies: A Comparative Study of the Effects of Isoflurane, Enflurane, Methoxyflurane and Halothane. Equine Vet. J. 10(1): 18-23, 1978. 3. Steffey, E.P. and Howland, D. Jr.: Comparison of Circulatory and Respiratory Effects of Isoflurane and Halothane Anesthesia in Horses. Am. J. Vet. Res. 41(5): 821-825, 1980. 4. Auer, J.A., Amend, J.F., Garner, H.E., Hutcheson, D.P. and Salem, C.A.: Electroencephalographic Responses During Volatile Anesthesia in Domestic Ponies: A Comparative Study of Isoflurane, Enflurane, Methoxyflurane and Halothane. Equine Practice 3: 130-134, 1979. 5. Klide A.M.: Cardiopulmonary Effects of Enflurane and Isoflurane in the Dog. Am. J. Vet. Res., Vol. 37, No. 2: 127-131, 1976. 6. Steffey, E.P. and Howland, D. Jr.: Isoflurane Potency in the Dog and Cat. Am. J. Vet. Res., Vol. 38, No. 11: 1833-1836, 1977. Manufactured for: Clipper Distributing Company, LLC St. Joseph, MO 64507, USA Product of United Kingdom ANADA # 200-070, Approved by FDA Distributed Exclusively By: Clipper Distributing Company, LLC St Joseph, MO 64507, USA Revised 2014 Product inquiries should be directed to Abbott Laboratories North Chicago, IL 60064, USA
Abbreviated New Animal Drug Application
ISOFLURANE- ISOFLURANE INHALANT CLIPPER DISTRIBUTING COMPANY LLC ---------- 03-A936/R3 5260-04-10 AND 5260-04-11 ISOFLURANE, USP WARNING: NOT FOR USE IN HORSES INTENDED FOR FOOD. INHALATION ANESTHETIC FOR USE IN HORSES AND DOGS CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION Isoflurane, USP is a nonflammable, nonexplosive general inhalation anesthetic agent. Its chemical name is 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, and its structural formula is: Each mL contains 99.9% isoflurane. Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. Samples stored in indirect sunlight in clear, colorless glass for five years, as well as samples directly exposed for 30 hours to a 2 amp,115 volt, 60 cycle long wave U.V. light were unchanged in composition as determined by gas chromatography. Isoflurane in one normal sodium methoxide-methanol solution, a strong base, for over six months consumed essentially no alkali, indicative of strong base stability. Isoflurane does not decompose in the presence of soda lime (at normal operating temperatures) and does not attack aluminum, tin, brass, iron or copper. CLINICAL PHARMACOLOGY Isoflurane, USP is an inhalation anesthetic. Induction and recovery from anesthesia with isoflurane are rapid. The level of anesthesia may be changed rapidly with isoflurane. Isoflurane is a profound respiratory depressant. RESPIRATION MUST BE MONITORED CLOSELY IN THE HORSE AND DOG AND SUPPORTED WHEN NECESSARY. As anesthetic dose is increased, both tidal volume 2,5 3,6 and respiratory rate decrease. This depression is partially reversed by surgical stimulation, even at deeper levels of anesthesia. Blood pressure decreases with induction of anesthesia but returns toward normal with surgical stimulation. Progressive increases in depth of anesthesia produce corresponding decreases in blood pressure; however, heart rhythm is stable and cardiac out Les hele dokumentet