País: Indonésia
Língua: indonésio
Origem: Badan Pengawas Obat dan Makanan RI - Indonesian Food and Drug Supervisory Agency
ADAPALENE, BENZOYL PEROXIDE
GENERO PHARMACEUTICALS - Indonesia
ADAPALENE, BENZOYL PEROXIDE
1 MG /25 MG
GEL
DUS, 1 TUBE PLASTIK @ 10 G
GENERO PHARMACEUTICALS - Indonesia
2020-09-26
Bahasa Inggris PHARMALENE B Adapalene Benzoyl Peroxide Gel Composition : Each gram of gel contains : Adapalene ............................................................................................................. 1 mg Benzoyl Peroxide ................................................................................................. 25 mg Mechanism of action: Adapalene acts on retinoid receptors. Mechanistically, Adapalene binds to specific Retinoic acid nuclear receptors but it does not bind to the cytosolic receptor protein. Although the exact mode of action of Adapalene is unknown, it is suggested that topical Adapalene normalizes the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Benzoyl Peroxide is an antibacterial agent which is believed to act by oxidizing proteins, including bacterial proteins, and reducing the population of Propionibacterium acnes which are usually abnormally present in the acne-affected pilosebaceous unit. Therefore, Adapalene and Benzoyl Peroxide act through different, but complementary, mechanisms that affect different aspects of acne therapy. Indication : Pharmalene B is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older. Dosage and administrations : Apply a thin film of Pharmalene B to affected areas of the face and/or trunk once daily after washing with a mild or soapless cleanser. Use a pea-sized amount for each area of the face (e.g., forehead, chin, each cheek). Avoid the eyes, lips and mucous membranes. Pharmalene B is not for oral, opthalmic, or intravaginal use. •The product can be used within 60 days after opened. DISETUJUI OLEH BPOM: 23/01/2020 ID: EREG10023811800025 Contraindication : Patients with history of hypersensitivity to Adapalene, Benzoyl Peroxide or to any other component of this preparation. Adverse Reactions : If skin irritation appears after application of Pharmalene B, the intensity is generally mild or moderate, with local tolerability signs and symptoms [erythema Leia o documento completo