Diazepam 10mg

Страна: Армения

Язык: английский

Источник: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում

Активный ингредиент:

diazepam

Доступна с:

Arpimed LLC

ИНН (Международная Имя):

diazepam

дозировка:

10mg

Фармацевтическая форма:

tablets

Тип рецепта:

Prescription

Характеристики продукта

SUMMARY PRODUCT CHARACTERISTIC (SPC)
DIAZEPAM
TABLETS
COMPOSITION
Each tablet_ _of _Diazepam 5 mg _contains:
_ACTIVE INGREDIENT: _diazepam – 5 mg;
_INACTIVE INGREDIENTS:_ microcrystalline cellulose, lactose
monohydrate, ethylcellulose, sodium starch
glycolate, magnesium stearate.
Each tablet_ _of _Diazepam 10 mg _contains:
_ACTIVE INGREDIENT: _diazepam – 10 mg;
_INACTIVE INGREDIENTS:_ microcrystalline cellulose, lactose
monohydrate, ethylcellulose, sodium starch
glycolate, magnesium stearate.
CHEMICAL NAME AND CAS NUMBER
7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one;
439-14-5.
PHARMACOLOGICAL GROUP AND ATC CODE
Benzodiazepine tranquilliser; N05BA01.
PHARMACOLOGY
DIAZEPAM is a long-acting benzodiazepine with anticonvulsant,
anxiolytic, sedative, muscle relaxant,
and amnestic properties.
The exact sites and mode of action of the benzodiazepines have not
been fully elucidated, but the
effects of the drugs appear to be mediated through the inhibitory
neurotransmitter γ-aminobutyric acid
(GABA). The drugs appear to act at the limbic, thalamic, and
hypothalamic levels of the CNS,
producing
anxiolytic,
sedative,
hypnotic,
skeletal
muscle
relaxant,
and
anticonvulsant
effects.
Benzodiazepines are capable of producing all levels of CNS
depression—from mild sedation to
hypnosis to coma. Specific binding sites with high affinity for
benzodiazepines have been detected in
the CNS, and the affinity of these sites for the drugs is enhanced by
both GABA and chloride. The
sites and actions of benzodiazepines within the CNS appear to involve
a macromolecular (oligomer or
possibly a tetramer) complex (GABAA-receptor-chloride ionophore
complex) that includes GABAA
receptors (GABA recognition sites), high-affinity benzodiazepine
receptors, and chloride channels,
although precise relationships between the sites of action of
benzodiazepines and GABA-regulated (-
gated)
chloride
channels
remain
to
be
more
fully
elucidated.
Allosteric
interactions
of
central
benzodiazepine receptors with GABAA receptors and subs