Страна: Армения
Язык: английский
Источник: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում
digoxin
Arpimed LLC
C01AA05
digoxin
0,25mg
tablets
(40/1x40/), in blister
Prescription
Registered
2015-09-24
SUMMARY PRODUCT CHARACTERISTIC (SPC) DIGOXIN 0,25 MG TABLETS l.lNAME OF THE MEDICINAL PRODUCT - Digoxin 1.2 INTERNATIONAL NON-PROPERTY NAME - Digoxin 2. Qualitative and quantitative composition Each tablet contains: active ingreelient: digoxin - 0.25 mg inaetive ingredients: see 6. 1. List of excipients 3. Pharmaceutical form Tablets White flat scored tablets 4. Clinical particulars 4. I Therapeutic indications Digoxin is a cardiac glycoside used in the management of supraventricular arrhythmias, and in heart failwe. ln heart fuilure the increased force of myocardial contraction results in increased cardiac output, decreased end-systolic volume, decreased heart size, and decreased end-diastolic pressure and volume. Increased blood flow through the kidneys results in diuresis with a reduction in oedema and blood volume. The decrease in puhnonary venous pressure relieves dyspnoea and orthopnoea. In atrial aruhythmias digoxin's actions cause a decrease in the conduction velocity through the AV node and an increase in the effective refractory period, thus reducing venhicular rate. ln addition there is a decrsase in the refractory period of the cardiac muscle and depression of the sinus node partly in response to the increase in vagal activity. ln atrialJibrillation, digoxin can cause rapid ventricular rates, and possibly ventricular fibrillation, and should be avoided. It may be given to reiieve an attack af paroxismal supraventricular tachycurdiu and has also been given to prevent further attacks. 4.2 Posology and method of administration Digoxin has a narrow therapeutic index. Effect appear within about 2 hours and the maximum effect may be reached in about 6 hours. Initially a loading dose may be given to digitalise the patient, although this may not be necessary in, for example, mild heart failure. Dosage depends on individual patient. Factors which may be considered include the patient,s age, Iean body-mass, renal status, thyroid status, elecholyte balance, degree of tissue oxygenation, and the nature of the und Прочитать полный документ