Krajina: Malajzia
Jazyk: angličtina
Zdroj: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
MEFENAMIC ACID
DUOPHARMA (M) SDN. BHD.
MEFENAMIC ACID
1000 Tablet Tablets
DUOPHARMA (M) SDN. BHD.
_Consumer Medication Information Leaflet (RIMUP)_ _ _ 1 PONTACID FORTE TABLET Mefenamic Acid (250mg) WHAT IS IN THE LEAFLET 1. What PONTACID is used for 2. How PONTACID work 3. Before you use PONTACID 4. How to use PONTACID 5. While you are using it 6. Side effects 7. Storage and Disposal of PONTACID 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT PONTACID IS USED FOR PONTACID capsule PONTACID is used in the treatment of menstrual cramps (period pain) and heavy menstrual periods. It is also used to relieve mild to moderate pain such as dental pain and soft tissue pain, osteoarthritis (degenerative joint disease), rheumatoid arthritis (systemic inflammatory disorder that affects joints). HOW PONTACID WORKS PONTACID capsule_ _ contains the active ingredient mefenamic acid. PONTACID_ _belongs to a group of medicines called Non- Steroidal Anti-Inflammatory Drugs (or NSAID) which relief pain, inflammation and fever. BEFORE YOU USE PONTACID _-_ _When you must not use it_ Do not take this medicine if you have an allergy to: mefenamic acid, the active ingredient any of the other ingredients listed at the end of this leaflet Do not take PONTACID if: you had diarrhoea with this medicine in the past. Diarrhoea may recur if you take PONTACID again. you have or have had ulceration or inflammation of the stomach or intestinal. you have impaired kidney function. you have had bronchospasm (constriction of your airway), rhinitis (Inflammation of the nasal mucous membrane) , urticaria (itching or hives) and the symptoms become worsen caused by Aspirin or NSAIDs. Do not give PONTACID to a child under 14 years. The safety and effectiveness of PONTACID in children have not been established. Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal. If you are not sure whether you should start taking this medicine, talk to Prečítajte si celý dokument
[Page 1/2] [Revision Date: 26.03.2019] PONTACID [DUOPHARMA (M) SDN BHD] DESCRIPTION: PONTACID CAPSULE 250 MG : A size 1, light blue / ivory capsule with marking ‘DUO 861’. PONTACID FORTE TABLET 500 MG : A blue, oblong, 17mm tablet with marking ‘dp 500’ on one side. COMPOSITION: PONTACID CAPSULE 250 MG: Each capsule contains Mefenamic Acid 250 mg. PONTACID FORTE TABLET 500 MG: Each tablet contains Mefenamic Acid 500 mg. PHARMACODYNAMICS: Mefenamic Acid has analgesic, anti-inflammatory and anti-pyretic action. It inhibits the enzymes of prostaglandin synthetase and also antagonizes the actions of prostaglandin at the receptor sites. These effects may also be responsible for its effectiveness in the treatment of primary dysmenorrhoea. The pain of primary dysmenorrhoea is thought to be due to increased abnormal uterine activity and uterine ischaemia, probably induced by release of PGF 2 α or due to increase in the ratio of PGF 2 α : PGE 2 . Prostaglandins are also believed to be responsible, at least in some part, for the symptoms of menorrhagia. PHARMACOKINETICS: Single and multiple studies have shown that mefenamic acid usually reaches peak plasma levels 2 to 4 hours after oral administration with a half life of 2 hours. Mefenamic acid and its metabolites are firmly bound to plasma proteins. Two distinct metabolic products, one a hydroxymethyl derivative and the other a carboxy derivative, have been identified in both plasma and urine. Mefenamic acid and its two metabolic derivatives become conjugated with glucuronic acid through an ester linkage which is alkali labile and are excreted principally in the urine, but also to some extent in the bile and faeces. Following a single dose, 67% of the total dose is excreted in the urine as unchanged drug or as one of two metabolites. 20% to 25% of the dose is excreted in the faeces during the first three days. INDICATIONS: For treatment of primary dysmenorrhoea and primary menorrhagia. Short term relief of mild to moderate pain such as dental pain and soft tissue Prečítajte si celý dokument