Država: Malezija
Jezik: angleščina
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
POTASSIUM CLAVULANATE; AMOXICILLIN TRIHYDRATE
Thye Pharma Sdn. Bhd
POTASSIUM CLAVULANATE; AMOXICILLIN TRIHYDRATE
100gm gm
Thye Pharma Sdn. Bhd
VETERINARY PACKAGE INSERT TP-AMOCLAVU WSP AMOXICILLIN & CLAVULANATE POTASSIUM 300/75 MG/G POWDER PRODUCT DESCRIPTION A white to off-white colour powder, which contains 300 mg/g of amoxicillin trihydrate and 75 mg/g of clavulanate potassium in 100g sachet. PHARMACODYNAMICS & PHARMACOKINETICS A combination of a beta-lactam antibiotic with a beta-lactamase inhibitor helps to restore the potency of amoxicillin against strains producing beta-lactamases. Amoxicillin is a bactericidal antibiotic, which acts by inhibiting the synthesis of bacterial cell walls during bacterial multiplication. It inhibits cross-linkage between the linear peptidoglycan polymer chains in the cell wall of Gram-positive bacteria. Broad spectrum penicillin antibiotic amoxicillin is active also against a limited range of Gram negative bacteria where the outer layer of bacteria cell-wall is made up of lypopolysaccharide and protein. There are three principal mechanisms of resistance to beta-lactam antibiotics: production of beta- lactamases, alteration of the penicillin binding protein (PBP), diminished outer membrane permeation. One of the most important mechanism of resistance is the inactivation of penicillin antibiotic with β-lactam enzymes produced by certain bacteria. These enzymes cleave the penicillin beta-lactam ring and render the penicillin drug inactive. Clavulanic acid acts as inhibitor of bacterial beta-lactamases. It prevents destruction of the beta-lactam ring and penicillins by beta-lactamase enzymes. The reaction is irreversible and both the enzyme and the clavulanate are destroyed while the antibiotic activity is preserved. The plasma pharmacokinetic properties of amoxicillin and clavulanic acid are relatively similar. Both compounds are stable in acid environment of the gastrointestinal tract. After oral administration, amoxicillin and clavulanic acid are readily absorbed. The absorption following oral administration does not appear to be inhibited by presence of food in the alimentary tract. Both compounds penetrate well int Preberite celoten dokument