Држава: Малезија
Језик: Енглески
Извор: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ACYCLOVIR
IMEKS PHARMA SDN. BHD.
ACYCLOVIR
25Tablet Tablets; 100Tablet Tablets
Salutas pharma GmbH
ACIC 200 TABLET Each tablet contains: Aciclovir 200mg. The tablet shall be white, round, biconvex with a score notch and a smooth surface. Diameter of the tablet is 12.1±0.2mm and height 4.5±0.4mm. ACIC 400 TABLET Each tablet contains: Aciclovir 400mg. The tablet shall be white, round, biconvex with a score notch and a smooth surface. Diameter of the tablet is 12.1±0.2mm and height 5.5±0.4mm. ACIC 800 TABLET Each tablet contains: Aciclovir 800mg. The tablet shall be white, oblong tablets with score notches on both sides and a smooth surface. Diameter of the tablet is 19.1±0.2mm and width 8.1±0.2mm and height 7.8±0.5mm. PROPERTIES Aciclovir inhibits viral replication by inhibiting the viral DNA synthesis. The aciclovir is phosphorylated by viral thymidine kinase. Aciclovir has 200 times greater affinity to herpes-virus-encoded thymidine kinase as compare to the mammalian thymidine kinase. The phosphorylation of aciclovir leads to formation of aciclovir monophosphate (aciclo-GMP). Aciclo-GMP is then catalysed by the normal cellular enzymes to form the aciclo-GDP & aciclo-GTP. Aciclo-GTP acts by competitive inhibition of viral DNA polymerase formation and the incorporation of aciclo-GTP into the viral DNA terminates the biosynthesis of the viral DNA strand. Aciclovir is a synthetic purine nucleoside analog, 9-((2-hydroxyethoxy) methyl) guanine with a linear side chain substituted for the cyclic sugar of the guanosine molecule. Aciclovir is active against the herpes viruses especially the herpes simplex type 1 and herpes simplex type 2. Aciclovir is less sensitive to the Varicella- zoster virus but is inhibited by concentrations that can be achieved clinically. Aciclovir has been proven to be 100 times more active than vidarabine and 10 times more active than idoxudine against herpes simplex type 1 in vitro. Aciclovir is selective against the viral infected cells and uninfected mammalian cells are not affected by aciclovir unless the concentrations exceed 70µg/ml. PHARMACOKINETICS The peak plasma concentratio Прочитајте комплетан документ