Nchi: Kanada
Lugha: Kiingereza
Chanzo: Health Canada
LISINOPRIL
MERCK CANADA INC
C09AA03
LISINOPRIL
5MG
TABLET
LISINOPRIL 5MG
ORAL
28/100
Prescription
ANGIOTENSIN-CONVERTING ENZYME INHIBITORS
Active ingredient group (AIG) number: 0121550003; AHFS:
CANCELLED POST MARKET
2015-03-02
PRODUCT MONOGRAPH PRINIVIL ® (lisinopril tablets, Merck Standard) Tablets 5, 10 and 20 mg PHARMACOLOGICAL CLASSIFICATION ANGIOTENSIN-CONVERTING ENZYME INHIBITOR MERCK CANADA INC. DATE OF REVISION: 16750 route Transcanadienne August 29, 2016 Kirkland, QC Canada H9H 4M7 CONTROL NO.: 194510 1 PRODUCT MONOGRAPH NAME OF DRUG PRINIVIL ® (lisinopril tablets, Merck Standard) Tablets 5, 10 and 20 mg PHARMACOLOGICAL CLASSIFICATION Angiotensin-Converting Enzyme Inhibitor ACTION AND CLINICAL PHARMACOLOGY PRINIVIL ® (lisinopril tablets) is an angiotensin-converting enzyme (ACE) inhibitor which is used in the treatment of hypertension, congestive heart failure and following myocardial infarction in hemodynamically stable patients. Angiotensin-converting enzyme is a peptidyl dipeptidase which catalyzes the conversion of angiotensin I to the pressor substance, angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II, which leads to increased plasma renin activity (due to removal of negative feedback of renin release) and decreased aldosterone secretion. Although the latter decrease is small, it results in a small increase in serum K + . In patients treated with PRINIVIL ® and a thiazide diuretic there was essentially no change in serum potassium (see PRECAUTIONS). 2 ACE is identical to kininase II. Thus, PRINIVIL ® may also block the degradation of bradykinin, a potent vasodilator peptide. However, the role that this plays in the therapeutic effects of PRINIVIL ® is unknown. While the mechanism through which PRINIVIL ® lowers blood pressure is believed to be primarily the suppression of the renin-angiotensin-aldosterone system, PRINIVIL ® also lowers blood pressure in patients with low-renin hypertension. PHARMACODYNAMICS Administration of PRINIVIL ® to patients with hypertension results in a reduction of both supine and standing blood pressure. Abrupt withdrawal of PRINIVIL ® has not been associated with a rapid increase in blood pressure. In most patients studied, after oral administration of an i Soma hati kamili