Nchi: Australia
Lugha: Kiingereza
Chanzo: Department of Health (Therapeutic Goods Administration)
Teicoplanin; Water for injections
Sanofi-Aventis Australia Pty Ltd
Medicine Registered
TARGOCID ® (TAR-GO-SID) _teicoplanin (tee-co-plan-in)_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Targocid. It does not contain all the available information. It does not take the place of talking to your doctor, or pharmacist. All medicines have risks and benefits. Your doctor or pharmacist has weighed the risks of you being given this medicine against the benefits they expect it will have. IF YOU HAVE ANY CONCERNS ABOUT BEING GIVEN THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET. YOU MAY NEED TO READ IT AGAIN. WHAT TARGOCID IS USED FOR Targocid injection is an antibiotic. It is used to kill bacteria responsible for infections which can occur in your blood, bones or joints. This antibiotic is generally used when the bacteria causing the infection are not satisfactorily eliminated by other antibiotics (eg penicillin) or when patients may be allergic to other antibiotics. Your doctor, however, may prescribe Targocid for another purpose. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY IT HAS BEEN PRESCRIBED FOR YOU. This medicine is only available with a doctor's prescription. There is no evidence that this medicine is addictive. BEFORE YOU ARE GIVEN IT _WHEN YOU MUST NOT BE GIVEN_ _IT_ DO NOT RECEIVE TARGOCID IF YOU ARE ALLERGIC TO IT OR ANY OF THE INGREDIENTS LISTED AT THE END OF THIS LEAFLET. Some symptoms of an allergic reaction include skin rash, itching, shortness of breath or swelling of the face, lips or tongue, which may cause difficulty in swallowing or breathing. DO NOT RECEIVE IT IF YOU ARE PREGNANT OR INTEND TO BECOME PREGNANT. It may affect your developing baby if you are given it during pregnancy. DO NOT RECEIVE IT IF YOU ARE BREASTFEEDING OR PLANNING TO BREASTFEED. It is not known whether Targocid passes into breast milk. DO NOT RECEIVE IT AFTER THE EXPIRY DATE (EXP) PRINTED ON THE PACK OR VIAL, If you receive it after the expiry date has passed, it may not work as well. DO NOT RECEIVE IT IF THE PACKAGE Soma hati kamili
Targocid PI 15784v3.0 1 PRODUCT INFORMATION TARGOCID NAME OF THE MEDICINE NON-PROPRIETARY NAME teicoplanin DESCRIPTION Teicoplanin is a glycopeptide-antibiotic produced by _Actinoplanes teichomyceticus_. It is presented as a sterile, pyrogen-free ivory white powder for reconstitution with water for injection. It is freely soluble in water and on reconstitution gives a clear solution. MICROBIOLOGY Teicoplanin is bactericidal or bacteriostatic on growing populations of susceptible Gram- positive organisms; depending on the sensitivity of the organism and antibiotic concentration. Teicoplanin inhibits the growth of susceptible organisms by interfering with cell-wall biosynthesis at a different site from that affected by β-lactams. Teicoplanin is therefore effective against staphylococci (including those resistant to methicillin and other β-lactam antibiotics) and streptococci. Some cross-resistance is observed between teicoplanin and the glycopeptide vancomycin. Teicoplanin has shown no cross-resistance to β-lactam antibiotics, macrolides, aminoglycosides, tetracycline, rifampicin or chloramphenicol. PHARMACOLOGY PHARMACOKINETICS In man, the plasma level profile after intravenous administration indicates a biphasic distribution (with a rapid distribution phase having a half-life of about 0.3 hours, followed by a more prolonged distribution phase having a half-life of 3 hours). At the end of the distribution phase, plasma levels and the subsequent time-concentration curves, are identical following intramuscular or intravenous administration of 3 mg/kg dose. Following intramuscular injection bioavailability is 100%; average peak plasma levels of 7.1 μg/mL are achieved in 3-4 hours following a dose of 3 mg/kg. The elimination half-life is 70-100 hours. The apparent volume of distribution at steady state is similar to total body water, i.e. 0.6 L/kg. Approximately 90-95 % of teicoplanin is bo Soma hati kamili