CALCITRIOL capsule liquid filled

Ülke: ABD

Dil: İngilizce

Kaynak: NLM (National Library of Medicine)

Aktif bileşen:

CALCITRIOL (UNII: FXC9231JVH) (CALCITRIOL - UNII:FXC9231JVH)

Mevcut itibaren:

KAISER FOUNDATION HOSPITALS

INN (International Adı):

CALCITRIOL

Kompozisyon:

CALCITRIOL 0.25 ug

Reçete türü:

PRESCRIPTION DRUG

Yetkilendirme durumu:

Abbreviated New Drug Application

Ürün özellikleri

CALCITRIOL - CALCITRIOL CAPSULE, LIQUID FILLED
KAISER FOUNDATION HOSPITALS
----------
CALCITRIOL CAPSULE, LIQUID FILLED
RX ONLY
DESCRIPTION
Calcitriol is a synthetic vitamin D analog which is active in the
regulation of the absorption of calcium
from the gastrointestinal tract and its utilization in the body.
Calcitriol Capsules contain 0.25 mcg or 0.5
mcg calcitriol, fractionated triglyceride of coconut oil, butylated
hydroxyanisole (BHA) and butylated
hydroxytoluene (BHT) as antioxidants. Gelatin capsule shells contain
glycerin, water, sorbitol, sorbitan,
mannitol, water, FD&C Yellow No. 6, FD&C Red #40, titanium dioxide and
iron oxide black.
Calcitriol is a white, crystalline compound which occurs naturally in
humans. It has a calculated
molecular weight of 416.65 and is soluble in organic solvents but
relatively insoluble in water.
Chemically, calcitriol is 9,10-
seco(5Z,7E)-5,7,10(19)-cholestatriene-1α, 3β, 25-triol and has the
following structural formula:
The other names frequently used for calcitriol are
1α,25-dihydroxycholecalciferol, 1,25-
dihydroxyvitamin D , 1,25-DHCC, 1,25(OH) D and 1,25-diOHC.
CLINICAL PHARMACOLOGY
Man's natural supply of vitamin D depends mainly on exposure to the
ultraviolet rays of the sun for
conversion of 7-dehydrocholesterol in the skin to vitamin D
(cholecalciferol). Vitamin D must be
metabolically activated in the liver and the kidney before it is fully
active as a regulator of calcium and
phosphorus metabolism at target tissues. The initial transformation of
vitamin D is catalyzed by a
vitamin D -25-hydroxylase enzyme (25-OHase) present in the liver, and
the product of this reaction is
25 hydroxyvitamin D [25-(OH)D ]. Hydroxylation of 25-(OH)D occurs in
the mitochondria of kidney
tissue, activated by the renal 25-hydroxyvitamin D -1
alpha-hydroxylase (alpha-OHase), to produce
1,25-(OH) D (calcitriol), the active form of vitamin D . Endogenous
synthesis and catabolism of
calcitriol, as well as physiological control mechanisms affecting
these processes, play a critical rol