Ülke: Malezya
Dil: İngilizce
Kaynak: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
CARVEDILOL
RANBAXY (MALAYSIA) SDN. BHD.
CARVEDILOL
100Units Units
RANBAXY (MALAYSIA) SDN. BHD.
CASLOT TABLETS (CARVEDILOL TABLETS) COMPOSITION CASLOT 6.25 MG Each tablet contains Carvedilol ………….6.25 mg CASLOT 12.5 MG Each tablet contains Carvedilol ………….12.5 mg CASLOT 25 MG Each tablet contains Carvedilol………….25.0 mg PRODUCT DESCRIPTION CASLOT 6.25 MG : Yellow coloured, circular, biconvex, uncoated mottled tablets with a score-line on one side and plain on the other. CASLOT 12.5 MG : Peach coloured, circular, biconvex, uncoated mottled tablets with a score-line on one side and plain on the other. CASLOT 25 MG : White to off-white, circular, biconvex, uncoated mottled tablets with a score-line on one side and plain on the other. DESCRIPTION Carvedilol is a nonselective β -adrenergic blocking agent with α 1 -blocking activity. It is chemically designated as (±)-1-Carbazol-4-yloxy-3-[[2-(o- methoxyphenoxy)ethyl]amino]-propan-2-ol. The molecular formula for carvedilol is C 24 H 26 N 2 O 4 and its molecular weight is 406.5. CARVEDILOL PHARMACOLOGY MECHANISM OF ACTION Carvedilol is a vasodilating non-selective β -blocking agent with antioxidant properties. Vasodilation is predominantly mediated through α 1- receptor antagonism. Carvedilol reduces the peripheral vascular resistance through vasodilation and suppresses the renin-angiotensin-aldosterone system through β -blockade. The activity of plasma renin is reduced and fluid retention is rare. Carvedilol has no intrinsic sympathomimetic activity and like propranolol, it has membrane stabilising properties. Carvedilol is a racemate of two stereoisomers. β -blockade is attributed to the S(-) enantiomer; in contrast, both enantiomers exhibit the same α 1 -blocking activity. Carvedilol is a potent antioxidant, a scavenger of reactive oxygen radicals and an anti-proliferative agent. Reported clinical studies have shown that the balance of vasodilation and β - blockade provided by carvedilol results in the following effects: − In hypertensive patients, a reduction in blood pressure is not associated with a concomitant increase in t Belgenin tamamını okuyun