Ülke: ABD
Dil: İngilizce
Kaynak: NLM (National Library of Medicine)
HYALURONATE SODIUM (UNII: YSE9PPT4TH) (HYALURONIC ACID - UNII:S270N0TRQY)
Bioniche Animal Health USA, Inc.
HYALURONATE SODIUM
HYALURONATE SODIUM 10 mg in 1 mL
INTRAVENOUS
PRESCRIPTION
NexHATM (hyaluronate sodium) injectable solution is indicated in the treatment of joint dysfunction of the carpus or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis. There are no known contraindications for the use of NexHATM (hyaluronate sodium) injectable solution in horses.
NexHATM injectable solution is supplied in cartons containing twelve x 4 mL (40 mg) vials.
Abbreviated New Animal Drug Application
NEXHA- HYALURONATE SODIUM INJECTION, SOLUTION BIONICHE ANIMAL HEALTH USA, INC. ---------- NEXHA [HYALURONATE SODIUM] INJECTABLE SOLUTION 10 MG/ML FOR INTRAVENOUS USE IN HORSES ONLY CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: NexHA (hyaluronate sodium) injectable solution is a clear, colorless solution of low viscosity. NexHA injectable solution is pyrogen free, sterile and does not contain a preservative. It is administered by intravenous injection. Hyaluronic acid, the conjugate acid of hyaluronate sodium, is extracted from the capsule of _Streptococcus spp._ and purified, resulting in a form which is essentially free of protein and nucleic acids. NexHA injectable solution is supplied in 4 mL (40 mg) vials. Each mL contains 10 mg hyaluronate sodium, 8.5 mg sodium chloride, 0.223 mg sodium phosphate dibasic and 0.04 mg sodium phosphate monobasic. The pH is adjusted to between 6.5 and 8.0 with sodium hydroxide or hydrochloric acid. CHEMISTRY: Hyaluronic acid, a glycosaminoglycan, can exist in the following forms depending upon the chemical environment in which it is found: as the acid, hyaluronic acid; as the sodium salt, sodium hyaluronate (hyaluronate sodium); or as the hyaluronate anion. These terms may be used interchangeably but in all cases, reference is made to the glycosaminoglycan composed of repeating subunits of D-glucuronic acid and N-acetyl-Dglucosamine linked together by glycosidic bonds. Since this product originates from a microbial source, there is no potential for contamination with dermatan or chondroitin sulfate or any other glycosaminoglycan. CLINICAL PHARMACOLOGY: Hyaluronic acid is a naturally occurring substance present in connective tissue, skin, vitreous humor and the umbilical cord in all mammals. High concentrations of hyaluronic acid are also found in the synovial fluid. It also constitutes the major component of the capsule of certain microorganisms. The hyaluronic acid produced by bacteria is the same structure and confi Belgenin tamamını okuyun