Ülke: Malezya
Dil: İngilizce
Kaynak: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ALFUZOSIN HYDROCHLORIDE
RANBAXY (MALAYSIA) SDN. BHD.
ALFUZOSIN HYDROCHLORIDE
3x10tablet Tablets
RANBAXY (MALAYSIA) SDN. BHD.
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ 1 RANFUZOSIN TABLETS Alfuzosin Hydrochloride (10mg) WHAT IS IN THIS LEAFLET 1. What RANFUZOSIN is used for 2. How RANFUZOSIN works 3. Before you use RANFUZOSIN 4. How to use RANFUZOSIN 5. While you are using RANFUZOSIN 6. Side effects 7. Storage and disposal of RANFUZOSIN 8. Product description 9. Manufacturer & Product registration holder 10. Date of revision WHAT RANFUZSOIN IS USED FOR RANFUZOSIN is used to treat symptoms of a medical condition in men called Benign Prostatic hypertrophy or BPH. BPH is a condition where the prostate gland (which is near your bladder) has become bigger making it more difficult for you to pass urine. This can lead to symptoms such as: Weak or interrupted stream of urine Feeling that you cannot empty your bladder completely Delay before you start to pass urine RANFUZOSIN is also used along with catheter in acute urinary retention (unability to pass urine) as a symptom of BPH. HOW RANFUZOSIN WORKS RANFUZOSIN contains active substance alfuzosin. Alfuzosin belongs to a group of medicines known called alpha-1- blockers. Alfuzosin works by relaxing the prostate gland muscle. This reduces the narrowing of the urethra and so makes it easier to pass urine. The prostate gland is situated under the bladder surrounding the urethra (the tube that takes your urine to the outside of the body). With age, the prostate gland may grow and press the urethra making it smaller. This may cause problems with urination such as frequent urination and difficulty in passing urine. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY RANFUZOSIN HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another reason. This medicine is available only with a doctor’s prescription. RANFUZOSIN is available as 10 mg tablets. BEFORE YOU USE RANFUZOSIN - _When you must not use it _ DO NOT TAKE RANFUZOSIN IF YOU HAVE AN ALLERGY TO: any medicine containing alfuzosin any of the ingredients of RANFUZOSIN, listed at the end of this leaflet So Belgenin tamamını okuyun
_For the use of registered medical practitioner only _ RANFUZOSIN (Alfuzosin Hydrochloride Modified Release Tablets 10mg) COMPOSITION Each modified release tablet contains: Alfuzosin Hydrochloride ………………………………….10 mg INACTIVE INGREDIENTS: Lactose, Povidone, Aerosil, Purified Talc, Magnesium Stearate, Hypromellose, Hydroxy propyl cellulose PRODUCT DESCRIPTION White to off-white, uncoated, round, biconvex tablets debossed with ‘RY10’ on one side of the tablet. DESCRIPTION RANFUZOSIN is a modified release formulation that contains alfuzosin hydrochloride as active ingredient, which is a selective peripherally acting antagonist of post-synaptic alpha1-adrerenoreceptors. Alfuzosin hydrochloride is chemically described as (R,S)-N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl) methylamino] propyl] tetrahydro-2-furancarboxamide hydrochloride. The empirical formula of alfuzosin hydrochloride is C 19 H 27 N 5 O 4 •HCl. The molecular weight of alfuzosin hydrochloride is 425.9. ALFUZOSIN PHARMACODYNAMICS & PHARMACOKINETICS PHARMACODYNAMICS_ _ Alfuzosin is an orally active quinazoline derivative. It is a selective peripherally acting antagonist of post-synaptic alpha1-adrerenoreceptors. Selectivity of alfuzosin for the alpha-1-adrenoreceptors located in the prostate, bladder base and prostatic urethra have reported _in vitro_. Clinical manifestations of Benign Prostatic Hypertrophy (BPH) are associated with infra vesical obstruction which is triggered by both anatomical (static) and functional (dynamic) factors. The functional component of obstruction arises from the tension of prostatic smooth muscle which is mediated by alpha- adrenoceptors. Activation of alpha-1-adrenoceptors stimulates smooth muscle contraction, thereby increasing the tone of the prostate, prostatic capsule, prostatic urethra and bladder base, and, consequently, increasing the resistance to bladder outflow. This in turn leads to outflow obstruction and possible secondary bladder instability. Alpha-blockade decreases infra vesic Belgenin tamamını okuyun