Страна: США
мова: англійська
Джерело: NLM (National Library of Medicine)
PHENYLBUTAZONE (UNII: GN5P7K3T8S) (PHENYLBUTAZONE - UNII:GN5P7K3T8S)
Sparhawk Laboratories, Inc.
INTRAVENOUS
PRESCRIPTION
For relief of inflammatory conditions associated with the musculoskeletal system in horses. Treated animals should not be slaughtered for food purposes. Parenteral injections should be made intravenously only; do not inject subcutaneously or intramuscularly. Use with caution in patients who have a history of drug allergy. For relief of inflammatory conditions associated with the musculoskeletal system in horses. Intravenous dosage (not subcutaneous or intramuscular use) : Horses : 1 to 2 g per 1,000 lb body weight (5 to 10 mL/1,000 lb) daily. Not for use in Horses intended for food. See package outsert for additional information. Approved by FDA under ANADA 200-371 Each mL contains: Phenylbutazone ............................. 200 mg Benzyl Alcohol Preservative .........10.45 mg Sodium hydroxide to adjust pH to 9.5 to 10.0 Water For Injection ...............................q.s.
INJECTABLE : For Horses only: 100 mL vials, 200 mg/mL (1 g/5 mL) Each mL contians 200 mg of phenylbutazone, 10.45 mg of benzyl alcohol as preservative, sodium hydroxide to adjust pH to 9.5 to 10.0, and water for injection, Q.S.
Abbreviated New Animal Drug Application
PHENYLBUTAZONE- PHENYLBUTAZONE INJECTION SPARHAWK LABORATORIES, INC. ---------- PHENYLBUTAZONE 20% INJECTION (PHENYLBUTAZONE) CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. NOT FOR USE IN HUMANS KEEP OUT OF REACH OF CHILDREN FOR HORSES ONLY APPROVED BY FDA UNDER ANADA # 200-371 DESCRIPTION: Phenylbutazone 20% Injection (phenylbutazone) is a synthetic, nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties. Chemically, phenylbutazone is 4-butyl-1,2- diphenyl-3,5-pyrazolidinedione. It is a pyrazolon derivative entirely unrelated to the steroid hormones, and has the following structural formula: BACKGROUND PHARMACOLOGY Kuzell, Payne, Fleming, and Denko demonstrated clinical effectiveness of phenylbutazone in acute rheumatism, gout, gouty arthritis and various other rheumatoid disorders in man. Anti-rheumatic and anti-inflammatory activity has been well established by Fabre, Domenjoz, Wilhelmi, and Yourish. Lieberman reported on the effective use of phenylbutazone in the treatment of painful conditions of the musculoskeletal system in dogs; including posterior paralysis associated with intervertebral disc syndrome, painful fractures, arthritis, and painful injuries to the limbs and joints. Joshua observed objective improvement without toxicity following long-term therapy of two aged arthritic dogs. Ogilvie and Sutter reported rapid response to phenylbutazone therapy in a review of 19 clinical cases including posterior paralysis, 1, 2, 3 4 5 6 7 8 9 10 11 12 13 posterior weakness, arthritis, rheumatism, and other conditions associated with lameness and musculoskeletal weakness. Camberos reported favorable results with phenylbutazone following intermittent treatment of Thoroughbred horses for arthritis and chronic arthrosis (e.g., osteoarthritis of medial and distal bones of the hock, arthritis of stifle and hip, arthros Прочитайте повний документ