Страна: Малайзія
мова: англійська
Джерело: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
METRONIDAZOLE
SUNWARD PHARMACEUTICAL SDN. BHD.
METRONIDAZOLE
1000 Tablet Tablets; 500 Tablet Tablets; 100 Tablet Tablets; 1000 Tablets
SUNWARD PHARMACEUTICAL SDN. BHD.
TRINAZOLE TABLET ® _Consumer Medication Information Leaflet (RIMUP)_ Metronidazole 200mg __________________________________________________________________________________________________________________ Page 1 WHAT IS IN THIS LEAFLET: 1. What Trinazole tablet is used for 2. How Trinazole tablet works 3. Before you use Trinazole tablet 4. How to use Trinazole tablet 5. While you are using it 6. Side effects 7. Storage & Disposal of Trinazole tablet 8. Product Description 9. Manufacturer and Product Registration Holder 10.Date of revision WHAT TRINAZOLE TABLET IS USED FOR It is used for the treatment of symptomatic trichomoniasis in females and males when the presence of trichomanad has been confirmed by appropriate laboratory procedures. Metronidazole is indicated in the treatment of asymptomatic females when organism is associated with endocervicitis, cervicitis or cervical erosion. T. vaginalis infection is a veneral disease. Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously if the organism has been found to be present, in order to prevent reinfection of the partner. Metronidazole is indicated in the treatment of acute intestinal amoebiasis (amoebic dysentry) and amoebic liver abscess. Metronidazole is also indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. HOW TRINAZOLE TABLET WORKS The active ingredient in the medicine is ‘ Metronidazole ’. It possesses direct trichomonacidal amebacidal activity against Trichomonas vaginalis and Entamoeba histolytica. The in vitro minimal inhibitory concentration for most strains of these organisms is 8 µg/ml or less. Its mechanism of antiprotozoal action is unknown. Metronidazole is active in vitro against most obligate anaerobes but does not appear to possess any clinically relevant activity against facultative anaerobes or obligate aerobes. Against susceptible organisms, metronidazole is generally bactericidal at concentrations equal to or slightly higher than the inhibitory concentrat Прочитайте повний документ
TRINAZOLE TABLET Each tablet contains:- Metronidazole 200mg PHARMACODYNAMICS: Metronidazole possesses direct trichomonacidal amebacidal activity against Trichomonas vaginalis and Etamoeba histolytica. The in vitro minimal inhibitory concentration for most strains of these organisms is 8ug/ml or less. Its mechanism of antiprotozoal action is unknown. Metronidazole is active in vitro against most obligate anaerobes but does not appear to possess any clinically relevant activity against facultative anaerobes or obligate aerobes. Against susceptable organisms, metroidazole is generally bactericidal at concentrations equal to or slighty higher than the inhibitory concentrations. Metronidazole has been shown to have in vitro and clinical activity against the following organisms: Anaerobic gram negative bacilli, including: Bacteroides fragilis group _(B. fragilis, B.ovatus, B.thetaiotaomicion, B.vulgatus)_ _Fusobacterium_ species Anaerobic gram positive bacilli, including: _Clostridium_ species and susceptible strains of Eubacterium. anaerobic gram positive cocci, including: _Peptococcus species, Peptostreptococcus_ species PHARMACOLOGY: Following oral administration, Metronidazole is well absorbed with peak plasma concentrations occuring between one and two hours after administration. For oral dosage form, the elimination half-life in healthy human is eight hours. The major route of elimination of Metronidazole and its metabolites is via the urine (60-80%) of the dose), with fecal excretion accounting for 6-15% of the dose. Renal clearance of Metronidazole is approximately 10ml/mim/1.73m. Metronidazole appears in cerebrospinal fluid, saliva and breast milk in concentrations similar to those found in plasma. Decreased renal funtion does not after the single-dose pharmacokinetics of Metronidazole. However, plasma clearance of metronidazloe is decreased in patients with decreased liver function. INDICATIONS: Metronidazole is indicated for the treatment of symptomatic trichomoniasis in females and males when the presence Прочитайте повний документ