Quốc gia: Úc
Ngôn ngữ: Tiếng Anh
Nguồn: Department of Health (Therapeutic Goods Administration)
Allopurinol
Arrow Pharma Pty Ltd
Allopurinol
APO-ALLOPURINOL™ TABLETS 1 APO-ALLOPURINOL™ TABLETS _Contains the active ingredient allopurinol _ CONSUMER MEDICINE INFORMATION _FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055 _ WHAT IS IN THIS LEAFLET This leaflet answers some common questions about APO- ALLOPURINOL (Allopurinol tablets). It does not contain all of the available information about APO- ALLOPURINOL tablets. It does not replace talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you or your child taking APO-ALLOPURINOL against the benefits he or she expects it will have. ASK YOUR DOCTOR OR PHARMACIST IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is APO- ALLOPURINOL and is available in tablets of two different strengths. The active ingredient is called allopurinol. Allopurinol belongs to a group of medicines called anti-uricaemic agents and is used to reduce the amount of uric acid in the body. Most commonly, high levels of uric acid in the body are related to gout. APO-ALLOPURINOL is available as a 100 mg and 300 mg tablet. APO-ALLOPURINOL is used to treat high levels of uric acid in the blood (hyperuricaemia) associated with gout or some other conditions. Your doctor will identify these other conditions if necessary, as they are very uncommon (e.g. Lesch-Nyhan Syndrome). Your doctor however, may have prescribed APO-ALLOPURINOL for another purpose not listed above. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY APO- ALLOPURINOL HAS BEEN PRESCRIBED FOR YOU. If you have any concerns, you should discuss this with your doctor. This medicine is only available with a doctor’s prescription. BEFORE YOU TAKE THIS MEDICINE _WHEN YOU MUST NOT TAKE IT _ Do not take APO-ALLOPURINOL if you are allergic to: • Allopurinol or any of the ingredients listed at the end of this leaflet including lactose. Some of the symptoms of an allergic reaction to APO-ALL Đọc toàn bộ tài liệu
APO-ALLOPURINOL- Product Information Page 1 of 10 PRODUCT INFORMATION APO-ALLOPURINOL (ALLOPURINOL) TABLETS NAME OF THE MEDICINE APO-ALLOPURINOL tablets contain 100 mg or 300 mg allopurinol. DESCRIPTION CHEMICAL STRUCTURE CHEMICAL NAME: 1,5-dihydro-4 _H_ -pyrazolo[3,4- _d_ ]pyrimidin-4-one. _ _ Allopurinol has the molecular formula C 5 H 4 N 4 O ( _CAS- 315-30-0)_ with a molecular weight of 136.1. Allopurinol is a white or off-white, almost odourless powder. It is very slightly soluble in water and in alcohol, and is practically insoluble in chloroform and in ether. It dissolves in dilute solutions of alkali hydroxides. Each APO-ALLOPURINOL tablet contains the excipients povidone, maize starch, lactose monohydrate and magnesium stearate. PHARMACOLOGY ACTIONS: Allopurinol inhibits xanthine oxidase, the enzyme which catalyses the conversion of hypoxanthine to xanthine, and of xanthine to urate/uric acid. Allopurinol decreases urate formation in two ways: 1. The inhibition of xanthine oxidase reduces the amount of hypoxanthine and xanthine converted to urate/uric acid. 2. This action makes more hypoxanthine and xanthine available for reutilisation in the purine metabolic cycle, which in turn, by a feedback mechanism, decreases overall _de novo_ purine formation. XO XO Hypoxanthine → xanthine → Urate/uric acid N N N N OH H NH N N N O H APO-ALLOPURINOL- Product Information Page 2 of 10 Since allopurinol decreases urate formation, it reduces urate/uric acid concentrations in both body fluids and urine. In contrast, the uricosuric agents which increase urate/uric acid excretion via the kidney will reduce the urate concentration in body fluids, but increase urate/uric acid concentration in urine. Reduction of the urate concentrations in body fluids by allopurinol permits mobilisation and dissolution of urate deposits anywhere in the body, the commonest sites being those in the skin, bones, joints and kidney interstitial tissue. Therapeutic effects therefore include: the resolution of skin tophi and the healing of Đọc toàn bộ tài liệu