Quốc gia: Nam Phi
Ngôn ngữ: Tiếng Anh
Nguồn: South African Health Products Regulatory Authority (SAHPRA)
Bm_squib
CAPOZIDE 50/25 TABLETS SCHEDULING STATUS: S3 PROPRIETARY NAME (and dosage form): CAPOZIDE 50/25 TABLETS COMPOSITION CAPOZIDE 50/25 is a combination of captopril 50 mg, designated chemically as D-3-mercapto-2-methylpropanoyl-L- proline (captopril), and 25 mg hydrochlorothiazide , a thiazide diuretic antihypertensive agent, per tablet. PHARMACOLOGICAL CLASSIFICATION Category A 7.1.3 - Other hypotensives. PHARMACOLOGICAL ACTION CAPOZIDE 50/25 is a combination of an angiotensin-converting enzyme inhibitor (captopril) and a diuretic (hydrochlorothiazide). With diuretic treatment, blood pressure and blood volume fall resulting in a rise in angiotension II levels which tend to blunt the hypotensive effect. Captopril blocks this rise in angiotensin II. Since captopril and hydrochlorothiazide lower blood pressure by different, though complementary mechanisms, their antihypertensive effects are additive, and, concurrent administration may permit the use of lower doses of each drug. Because captopril reduces the production of aldosterone, its combination with hydrochlorothiazide may also minimise diuretic induced hypokalemia. Captopril may also interfere with the degradation of the vasodepressor peptide, bradykinin. Increased concentrations of bradykinin or prostaglandin E2 may also have a role in the therapeutic effect of captopril. Thiazides increase excretion of sodium and chloride in approximately equal amounts.Natriuresis causes a secondary loss of potassium and bicarbonate. Pharmacokinetics: Captopril: After oral administration of therapeutic doses of captopril, rapid absorption occurs with peak blood levels at about one hour. The presence of food in the gastrointestinal tract reduces absorption by about 30 to 40%; captopril should therefore be given one hour before meals. Average minimal absorption i Đọc toàn bộ tài liệu