Quốc gia: Indonesia
Ngôn ngữ: Tiếng Indonesia
Nguồn: Badan Pengawas Obat dan Makanan RI - Indonesian Food and Drug Supervisory Agency
PRILOCAINE HYDROCHLORIDE
B.BRAUN PHARMACEUTICAL INDONESIA - Indonesia
PRILOCAINE HYDROCHLORIDE
20 Mg
INJEKSI
DUS, 10 AMPUL @ 5 ML
SINTETICA SA - Switzerland
2021-05-01
COMPOSITION Each mL of TAKIPRIL contains prilocaine hydrochloride 20 mg. DESCRIPTION TAKIPRIL is a clear and colourless solution for injection that contains prilocaine hyperbaric, a local anaesthetic, belonging to the category of the amides. TAKIPRIL is used to anaesthetise specific parts of the body and prevent pain during surgery in adults. By means of the excipient glucose, the density of TAKIPRIL is 1.026 g/g at 20°C, equivalent to 1.021 g/g at 37°C. This medicinal product contains less than 1 mmol sodium (23 mg) per dose (maximum dose equal to 4 mL of TAKIPRIL), i.e. essentially “sodium-free”. PHARMACOLOGY _PHARMACODYNAMIC_ Prilocaine is an amide-type local anaesthetic. Prilocaine inhibits the function of the excitable structures (e.g. all types of nerve fibres [sensory, motor, autonomous nerve fibres]). It inhibits the excitability of sensory pain receptors and the conductivity of the sensory nerve fibres, at local level and in a reversible way, reducing the perception of pain and, subsequently, that of cold, heat, touch and pressure. Prilocaine reduces membrane permeability to sodium. This reduces the excitability of the nerve fibres in accordance with its concentration, through reducing the sudden peak sodium permeability, needed to form the potential for action. The effect depends on the pH of the substance and the pH of the environment. The local anaesthetic effect is due to the protonated form. In inflamed tissues, the effect of the local anaesthetics is lower because of the lower pH of the environment. _PHARMACOKINETIC _ The plasma concentration should be negligible for intrathecal use. The terminal elimination half-life of prilocaine is 1.6 hours. The plasma protein bond is approximately 55%. The bioavailability of prilocaine at the application site is 100%. INDICATIONS TAKIPRIL is indicated in adults for spinal anaesthesia in short term surgical procedures (not more than 45 minutes). CONTRAINDICATIONS TAKIPRIL is must not be used in patients with: Hypersensitivity to prilocaine hydrochlori Đọc toàn bộ tài liệu