Quốc gia: Úc
Ngôn ngữ: Tiếng Anh
Nguồn: Department of Health (Therapeutic Goods Administration)
aciclovir
GlaxoSmithKline Australia Pty Ltd
Aciclovir
Medicine Registered
Registered
ZOVIRAX OPHTHALMIC (EYE) OINTMENT _Acyclovir_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Zovirax ophthalmic ointment. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you using Zovirax ophthalmic ointment against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH YOUR MEDICINE. You may need to read it again. WHAT ZOVIRAX OPHTHALMIC OINTMENT IS USED FOR Zovirax ophthalmic ointment is used for the treatment of herpes simplex virus infections of the eye. Aciclovir (the active ingredient in Zovirax ophthalmic ointment) belongs to a group of medicines called "anti-virals". Zovirax ophthalmic ointment works by stopping the production of the herpes simplex virus. Zovirax ophthalmic ointment does not get rid of the virus from your body. Zovirax ophthalmic ointment is only suitable for use in the eye. Your doctor may have prescribed Zovirax ophthalmic ointment for another purpose. Ask your doctor or pharmacist if you have any questions about why Zovirax ophthalmic ointment has been prescribed for you. There is no evidence that Zovirax ophthalmic ointment is addictive This medicine is available only with a doctor's prescription. BEFORE YOU USE ZOVIRAX OPHTHALMIC OINTMENT _WHEN YOU MUST NOT USE IT_ DO NOT USE ZOVIRAX OPHTHALMIC OINTMENT IF: • YOU HAVE OR HAVE HAD AN ALLERGY TO ZOVIRAX, ACICLOVIR, VALACICLOVIR OR ANY OF THE INGREDIENTS LISTED AT THE END OF THIS LEAFLET DO NOT USE ZOVIRAX OPHTHALMIC OINTMENT IF THE PACKAGING IS TORN OR SHOWS SIGNS OF TAMPERING. DO NOT USE ZOVIRAX OPHTHALMIC OINTMENT IF THE EXPIRY DATE (EXP) PRINTED ON THE PACK HAS PASSED. If you use this medicine after the expiry date has passed, it may not work as well. DO NOT USE ZOVIRAX OPHTHALMIC OINTMENT 28 DAYS AFTER FIRST OPENING THE TUBE. IF YOU ARE NOT Đọc toàn bộ tài liệu
1 PRODUCT INFORMATION ZOVIRAX OPHTHALMIC OINTMENT NAME OF THE MEDICINE: Aciclovir DESCRIPTION: Aciclovir is a synthetic acyclic purine nucleoside analogue. Its chemical name is 9-((2-hydroxyethoxy)methyl)guanine. It is a white crystalline powder. Each gram of Zovirax Ophthalmic Ointment contains 30 mg of aciclovir in white soft paraffin base (aciclovir 3 per cent). PHARMACOLOGY: MICROBIOLOGY: Aciclovir is an antiviral agent which is active _in vitro_ against _Herpes simplex_ virus (HSV) types I and II. However, the relationship between _in vitro_ sensitivity of herpes viruses to aciclovir and clinical response to therapy has yet to be established. Aciclovir needs to be phosphorylated to the active compound, aciclovir triphosphate, in order to become active against the virus. Such conversion is very limited in normal cells and in addition cellular DNA polymerase is not very sensitive to the active compound. However, in infected cells HSV or VZV-coded thymidine kinase facilitates the conversion of aciclovir to aciclovir monophosphate which is then converted to aciclovir triphosphate by cellular enzymes. Aciclovir triphosphate acts as an inhibitor of, and substrate for, the herpes-specified DNA polymerase, preventing further viral DNA synthesis. PHARMACOKINETICS: Aciclovir is absorbed through the corneal epithelium and superficial ocular tissues, and achieves significant concentrations in aqueous humour. Small quantities (2-16% of the applied dose) appear in the urine. In animal studies low levels of aciclovir could be detected in blood after topical application to the eye. INDICATIONS: Treatment of _Herpes simplex_ keratitis. CONTRAINDICATIONS: Patients with known hypersensitivity to aciclovir or valaciclovir. PRECAUTIONS: Patients should be informed that transient mild stinging immediately following application may occur. Patients should avoid wearing contact lenses when using Zovirax Ophthalmic Ointment. Resistant strains have been isolated _in vitro_ and in animals following treatment with aciclovir. HSV str Đọc toàn bộ tài liệu