国家: 美国
语言: 英文
来源: NLM (National Library of Medicine)
ETOMIDATE (UNII: Z22628B598) (ETOMIDATE - UNII:Z22628B598)
American Regent, Inc.
ETOMIDATE
ETOMIDATE 2 mg in 1 mL
PRESCRIPTION DRUG
Abbreviated New Drug Application
ETOMIDATE- ETOMIDATE INJECTION, SOLUTION AMERICAN REGENT, INC. ---------- ETOMIDATE INJECTION RX ONLY DESCRIPTION Etomidate Injection is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0). It is intended for the induction of general anesthesia by intravenous injection. The drug etomidate is chemically identified as (R)-(+)-ethyl-1-(1 -phenylethyl)-1H-imidazole-5- carboxylate and has the following structural formula: CLINICAL PHARMACOLOGY Etomidate is a hypnotic drug without analgesic activity. Intravenous injection of etomidate produces hypnosis characterized by a rapid onset of action, usually within one minute. Duration of hypnosis is dose dependent but relatively brief, usually three to five minutes when an average dose of 0.3 mg/kg is employed. Immediate recovery from anesthesia (as assessed by awakening time, time needed to follow simple commands and time to perform simple tests after anesthesia as well as they were performed before anesthesia), based upon data derived from short operative procedures where intravenous etomidate was used for both induction and maintenance of anesthesia, is about as rapid as, or slightly faster than, immediate recovery after similar use of thiopental. These same data revealed that the immediate recovery period will usually be shortened in adult patients by the intravenous administration of approximately 0.1 mg of intravenous fentanyl, one or two minutes before induction of anesthesia, probably because less etomidate is generally required under these circumstances (consult the package insert for fentanyl before using). The most characteristic effect of intravenous etomidate on the respiratory system is a slight elevation in arterial carbon dioxide tension (PaCO ). See also ADVERSE REACTIONS. Reduced cortisol plasma levels have been reported with induction doses of 0.3 mg/kg etomidate. These persist for approximately 6 to 8 hours and appear to be unresponsive to ACTH administration. The intravenous adm 阅读完整的文件