资料单张
NIMOTOP
®
CMI
1
NIMOTOP
®
(NEE·MOE·TOP)
_nimodipine_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS
LEAFLET
This leaflet answers some common
questions about Nimotop. This
leaflet does not contain all the
available information. It does not
take the place of talking to your
doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Nimotop
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR, NURSE OR PHARMACIST.
KEEP THIS LEAFLET WITH THE
MEDICINE.
You may need to read it again
WHAT NIMOTOP IS
USED FOR
Nimotop tablets and infusion
solution are used to prevent or to
treat a lack of blood supply in the
brain caused by narrowing of the
blood vessels after a haemorrhage
(burst blood vessel in the brain).
This medicine belongs to a group of
drugs called calcium channel
blockers. Nimotop works by
relaxing the smooth muscle of the
small blood vessels in the brain.
This allows narrowed vessels to
open up, thereby increasing blood
flow, reducing blood pressure, and
improving circulation.
YOUR DOCTOR MAY PRESCRIBE THIS
MEDICINE FOR ANOTHER USE. IF YOU
WANT MORE INFORMATION, ASK YOUR
DOCTOR.
If you have any further questions on
your Nimotop treatment, or are
unsure of the information, please
see your doctor, nurse or dispensing
pharmacist, who will be able to
assist you.
BEFORE YOU TAKE
NIMOTOP
_WHEN YOU MUST NOT TAKE IT _
DO NOT TAKE NIMOTOP TABLETS OR
INFUSION SOLUTION IF YOU HAVE AN
ALLERGY TO:
nimodipine, the active
ingredient in Nimotop
any of the ingredients listed at
the end of this leaflet.
Some of the symptoms of an
allergic reaction may include:
shortness of breath
wheezing or difficulty breathing
swelling of the face, lips,
tongue or oth
阅读完整的文件
产品特点
110401 NIMOTOP PI
1
PRODUCT INFORMATION
NIMOTOP
®
NIMODIPINE
NAME OF THE MEDICINE
Nimodipine belongs to the class of pharmacological agents
known as calcium
channel blockers. Nimodipine is isopropyl (2 - methoxyethyl) 1,
4 - dihydro - 2, 6 -
dimethyl - 4 - (3 - nitrophenyl) - 3, 5 -
pyridine - dicarboxylate. It is a racemic mixture
with a molecular weight of 418.5 and a molecular formula of C
21
H
26
N
2
O
7
. The CAS
Registry Number is: 66085-59-4. The structural formula is:
DESCRIPTION
Nimodipine is a yellow crystalline substance, practically
insoluble in water.
Nimodipine is light sensitive but to a much lesser degree than
nifedipine.
Nimotop is available as tablets containing 30 mg nimodipine or a
0.2 mg/mL
solution for infusion. Nimotop tablets contain cellulose
– microcrystalline, povidone,
starch - maize, crospovidone, magnesium
stearate, hypromellose, macrogol 4000,
titanium dioxide and iron oxide yellow as excipients. Nimotop
solution for infusion
contains ethanol 96% (200 mg/mL), macrogol 400, sodium citrate
and citric acid –
anhydrous as excipients.
PHARMACOLOGY
Nimodipine is a calcium channel blocking agent belonging
to the 1,4-dihydropyridine
group. The mechanism(s) of nimodipine's
clinical benefit in patients with
subarachnoid haemorrhage has not been fully elucidated. Current
evidence suggests
that it may have a preferential cerebral vasodilator action and/or
a direct effect
involving prevention of calcium overload in neurons. It dilates
the small resistance
cerebral vessels and increases the cerebral blood flow, the
increased perfusion
being generally more pronounced in brain regions with preliminary
damage and
restricted circulation than in healthy
阅读完整的文件