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PRODUCT INFORMATION
ORUDIS
CAPSULES, SR CAPSULES & SUPPOSITORIES
NAME OF THE MEDICINE
NON-PROPRIETARY NAME
Ketoprofen
CHEMICAL STRUCTURE
CAS NUMBER
22071-15-4
DESCRIPTION
Ketoprofen is DL-2-(3-benzoylphenyl) propionic acid. It is a white or off-white powder with
melting point of about 93°C. MW: 254.3. Ketoprofen is very slightly soluble in water at
20°C, 2% soluble in dimethylformide and readily soluble in benzene, ethanol, chloroform,
acetone and ethyl acetate at 20°C.
PHARMACOLOGY
Animal pharmacological studies have shown that ketoprofen has anti-inflammatory,
analgesic and antipyretic properties. It also inhibits prostaglandin synthetase. Ketoprofen
has been shown to possess antibradykinin activity in guinea pigs and mice. Inhibition of
platelet aggregation has been demonstrated in rabbits.
Ketoprofen reduces joint pain and inflammation and facilitates increase in mobility and
functional independence. As with other non-steroidal anti-inflammatory agents, it does not
cure the underlying disease.
PHARMACOKINETICS
Ketoprofen is readily absorbed from the gastrointestinal tract, peak plasma concentration
occur 0.5 to 2 hours after a single dose. Some retardation in absorption occurs with food.
The plasma half-life is about 1.6 to 1.9 hours. Binding to serum proteins (to albumin) of
about 62 to 93% has been observed.
Major route of metabolism involves glucuronide formation. Traces also of ring hydroxylated
derivatives have been detected. Metabolites are
not biologically active.
Ketoprofen doe
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