资料单张
RAMPIL 1,25 MG CAPSULE
RAMPIL 2,5 MG CAPSULE
RAMPIL 5 MG CAPSULE
RAMPIL 10 MG CAPSULE
SCHEDULING STATUS:
S3
PROPRIETARY NAME
(and dosage form):
RAMPIL 1,25 MG CAPSULE
RAMPIL 2,5 MG CAPSULE
RAMPIL 5 MG CAPSULE
RAMPIL 10 MG CAPSULE
COMPOSITION
RAMPIL 1,25 mg - Each capsule contains 1,25 mg of
ramipril
.
RAMPIL 2,5 mg - Each capsule contains 2,5 mg of ramipril.
RAMPIL 5 mg - Each capsule contains 5 mg of ramipril.
RAMPIL 10 mg - Each capsule contains 10 mg of ramipril.
PHARMACOLOGICAL CLASSIFICATION
A 7.1.3 Other hypotensives
PHARMACOLOGICAL ACTION
Ramipril inhibits angiotensin I-converting enzyme (ACE) activity. It inhibits the conversion of the relatively inactive
angiotensin I to the active angiotensin II.
Angiotensin II is a potent vasocontrictor and stimulates the release of aldosterone.
Decreased angiotensin II levels result in a decrease in vasopressor activity and reduction in aldosterone secretion, which
may result in small increases in serum potassium.
It is also thought that ACE inhibition may inhibit degradation of bradykinin, leading to increased bradykinin levels.
Pharmacokinetics:
The extent of absorption after oral administration is 60% with wide variability between patients. The plasma half-life is
increased in renal impairment. The time to achieve peak serum concentration is within 1 hour. Ramipril is renally
eliminated and excreted 100% unchanged in the urine.
INDICATIONS
RAMPIL capsules are indicated for the following:
• Mild to moderate hypertension.
• Cardiac failure following myocardial infarction.
• To reduce proteinuria and the decline in glomerular filtration rate in patients with diabetic nephropathy and
hypertension.
• To reduce the risk of myocardial infarction, stroke or cardiovascular death and to reduce the ne
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