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TRAVOCORT CREAM
SCHEDULING STATUS:
S4
PROPRIETARY NAME
(and dosage form):
TRAVOCORT CREAM
Broad-spectrum antimycotic
with a corticoid additive
COMPOSITION
1 g Travocort contains
isoconazole
nitrate (1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)-phenethyl]-imidazole, nitrate)
10 mg and
diflucortolone
valerate (6alpha,9-difluoro-11beta-hydroxy-21-valeryloxy-16alpha-methyl-1,4-pregna- diene-
3,20-dione) 1 mg in an easy-to-remove low fat base o/w emulsion.
PHARMACOLOGICAL CLASSIFICATION
A. 13.4.1 Corticosteroids with anti-infective agents.
PHARMACOLOGICAL ACTION
Isoconazole nitrate is for use in the treatment of superficial fungal diseases of the skin. It is effective against
dermatophytes and yeasts, yeast-like fungi and moulds, as well as against the causative organism of tinea versicolor and
that of erythrasma.
Diflucortolone valerate suppresses inflammation in inflammatory and allergic skin conditions and alleviates the
subjective complaints such as itching, burning and pain.
INDICATIONS
Fungal infections of hairless and hairy skin, eg in the region of the hands, the interdigital spaces of the feet, and in the
inguinal and genital regions.
Because of the addition of diflucortolone valerate, Travocort is indicated for the initial or intermediate treatment of those
fungal diseases which are accompanied by highly inflammatory or eczematous skin conditions.
CONTRA-INDICATIONS
Tuberculous and syphilitic processes in the area to be treated, virus diseases (herpes simplex, vaccinia, varicella and
smallpox).
Potent topical corticosteroid preparations (Travocort) should not be applied to any skin crease areas.
Corticosteroids have been shown to be teratogenic in animals following dermal application. As these agents are absorbed
percutaneously, teratogenicity following topical application cannot be excluded. Therefore Tra
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