البلد: الولايات المتحدة
اللغة: الإنجليزية
المصدر: NLM (National Library of Medicine)
AMPICILLIN SODIUM (UNII: JFN36L5S8K) (AMPICILLIN - UNII:7C782967RD)
GC Hanford Manufacturing Company
AMPICILLIN SODIUM
AMPICILLIN 1 g
INTRAVENOUS
PRESCRIPTION
Ampicillin sodium is indicated in the treatment of susceptible strains of the organisms causing the following infections in the horse: Respiratory tract infections (pneumonia and strangles) due to Staphylococcus spp., Streptococcus spp. (including S. equi ), E. coli, and Proteus mirabilis . Skin and soft tissue infections (abscesses and wounds) due to Staphylococcus spp., Streptococcus spp., E. coli , and Proteus mirabilis. As with all antibiotics, appropriate in vitro culturing and susceptibility testing of samples taken before treatment should be conducted. The use of this drug is contraindicated in animals with a history of an allergic reaction to penicillin.
Ampicillin Sodium is supplied in vials containing 1 gram and 3 grams of ampicillin activity. Store dry powder at room temperature, 15° to 30°C (59° to 86°F). NDC 10515-335-01 1 gm vial NDC 10515-335-03 3 gm vial ANADA 200-335 Approved by FDA Manufactured by: G.C. Hanford Mfg. Co. Syracuse, NY 13201 INS15793 03 7/2011
Abbreviated New Animal Drug Application
AMPICILLIN SODIUM- AMPICILLIN SODIUM INJECTION, POWDER, FOR SOLUTION GC HANFORD MANUFACTURING COMPANY ---------- AMPICILLIN SODIUM FOR INTRAVENOUS OR INTRAMUSCULAR USE IN HORSES ONLY DESCRIPTION Ampicillin sodium is a semisynthetic penicillin with a broad spectrum of activity. Ampicillin is derived from the penicillin nucleus, 6-aminopenicillanic acid (6 APA). Chemically it is D(-)α-aminobenzyl penicillin sodium salt. ACTION Ampicillin sodium provides bactericidal activity against a wide range of common Gram-positive and Gram-negative pathogens. Ampicillin’s activity occurs during the stage of active multiplication of the pathogen and acts through inhibition of biosynthesis of cell wall mucopeptide. _In vivo _studies have demonstrated the susceptibility of many strains of the following Gram-positive bacteria: _Staphylococcus_ spp. and_ Streptococcus_ spp. (including _S. equi_). _In vivo_ studies have also demonstrated the susceptibility of many strains of the following Gram-negative bacteria:_ E. coli_ and _Proteus mirabilis_. Because it does not resist destruction by penicillinase, it is not effective against penicillinase-producing bacteria, particularly resistant staphylococci. Most strains of Pseudomonas, Klebsiella and Aerobacter are resistant. Ampicillin sodium diffuses readily into all body tissues and fluids, with the exception of brain and spinal fluid except when the meninges are inflamed. It produces high and persistent blood levels. Most of the ampicillin is excreted unchanged in the urine. INDICATIONS Ampicillin sodium is indicated in the treatment of susceptible strains of the organisms causing the following infections in the horse: Respiratory tract infections (pneumonia and strangles) due to _Staphylococcus_ spp., _Streptococcus _spp. (including _S. equi_), _E. coli,_ and _Proteus mirabilis_. Skin and soft tissue infections (abscesses and wounds) due to _Staphylococcus _spp., _Streptococcus_ spp., _E._ _coli_, and _Proteus mirabilis._ As with all antibiotics, appropriate in vitroculturing and s اقرأ الوثيقة كاملة