País: Austràlia
Idioma: anglès
Font: Department of Health (Therapeutic Goods Administration)
Perindopril arginine
Servier Laboratories (Australia) Pty Ltd
Medicine Registered
COVERSYL ® 2.5MG COVERSYL ® 5MG COVERSYL ® 10MG _perindopril (pronounced per-in-do-pril)_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about COVERSYL. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of taking COVERSYL against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT COVERSYL IS The name of your medicine is COVERSYL. The medicine contains the active ingredient perindopril arginine. Perindopril belongs to a group of medicines called angiotensin converting enzyme (ACE) inhibitors. WHAT COVERSYL IS USED FOR COVERSYL is available only with a doctor's prescription. COVERSYL lowers high blood pressure, a condition which doctors call hypertension. Everyone has blood pressure. This pressure helps get your blood all around the body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have high blood pressure when your blood pressure stays higher than is needed, even when you are calm or relaxed. There are usually no symptoms of high blood pressure. The only way of knowing that you have it is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems. You may feel fine and have no symptoms, but eventually it can cause stroke, heart disease and kidney failure. COVERSYL helps lower your blood pressure. You may be prescribed COVERSYL for heart failure. Heart failure means that the heart muscle cannot pump blood strongly enough to supply all the blood needed throughout the body. Heart failure is not the same as heart attack and does not mean that the heart stops working. Some people develop heart failure after having Llegiu el document complet
COVERSYL ® (PERINDOPRIL ARGININE) – PRODUCT INFORMATION 1 (18) Version 16a PRODUCT INFORMATION NAME OF THE DRUG _COVERSYL_ _®_ _ 2.5MG _ Perindopril arginine 2.5mg _COVERSYL_ _®_ _ 5MG _ Perindopril arginine 5mg _COVERSYL_ _®_ _ 10MG _ Perindopril arginine 10mg DESCRIPTION COVERSYL is perindopril arginine which has the chemical name, L-arginine (2S, 3aS, 7aS) - 1 - N - [ (S) -1 - ethoxycarbonyl butyl ] - L - alanyl) perhydroindole-2 - carboxylate (code name S9490-6). Perindopril is a dipeptide monoacid monoester with a perhydroindole group and no sulphydryl radical. Perindopril arginine is a white powder, readily soluble in purified water, slightly soluble in 95% ethanol and practically insoluble in chloroform. Perindopril has five asymmetric centres. The drug is synthesised stereoselectively so that it is a single enantiomer (all S stereochemistry). _ _ _CAS Registry Number_: 612548-45-5 _ _ _Molecular formula_: C 19 H 32 N 2 O 5 , C 6 H 14 N 4 O 2 _Chemical structure_: , N H H COOH O N H CH 3 C H 3 O O C H 3 N H 2 N H NH COOH NH 2 _Excipients: _ Lactose, magnesium stearate, maltodextrin, silica - colloidal anhydrous, sodium starch glycollate (type A), macrogol 6000. All tablet coatings also include glycerol, hypromellose and titanium dioxide. Specific to: · COVERSYL 5MG - premix for light-green colour coating [copper chlorophyllin (E141ii)] · COVERSYL 10MG - premix for green colour coating [copper chlorophyllin (E141ii)] COVERSYL ® (PERINDOPRIL ARGININE) – PRODUCT INFORMATION 2 (18) Version 16a PHARMACOLOGY MECHANISM OF ACTION Perindopril (prodrug), following hydrolysis to perindoprilat, inhibits angiotensin converting enzyme (ACE) both in vitro and Llegiu el document complet