Coversyl

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Perindopril arginine

Available from:

Servier Laboratories (Australia) Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

COVERSYL
®
 2.5MG
COVERSYL
®
 5MG
COVERSYL
®
 10MG

_perindopril (pronounced per-in-do-pril)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS
LEAFLET
This leaflet answers some common
questions about COVERSYL. It does
not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of taking COVERSYL
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST. KEEP THIS
LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT COVERSYL IS
The name of your medicine is
COVERSYL. The medicine contains
the active ingredient perindopril
arginine. Perindopril belongs to a
group of medicines called
angiotensin converting enzyme
(ACE) inhibitors.
WHAT COVERSYL IS
USED FOR
COVERSYL is available only with a
doctor's prescription.
COVERSYL lowers high blood
pressure, a condition which doctors
call hypertension.
Everyone has blood pressure. This
pressure helps get your blood all
around the body. Your blood
pressure may be different at different
times of the day, depending on how
busy or worried you are. You have
high blood pressure when your blood
pressure stays higher than is needed,
even when you are calm or relaxed.
There are usually no symptoms of
high blood pressure. The only way of
knowing that you have it is to have
your blood pressure checked on a
regular basis. If high blood pressure
is not treated it can lead to serious
health problems. You may feel fine
and have no symptoms, but
eventually it can cause stroke, heart
disease and kidney failure.
COVERSYL helps lower your blood
pressure.
You may be prescribed COVERSYL
for heart failure. Heart failure means
that the heart muscle cannot pump
blood strongly enough to supply all
the blood needed throughout the
body. Heart failure is not the same as
heart attack and does not mean that
the heart stops working.
Some people develop heart failure
after having

Summary of Product characteristics

COVERSYL
®
 (PERINDOPRIL ARGININE) – PRODUCT INFORMATION 

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PRODUCT INFORMATION 

NAME OF THE DRUG 

_COVERSYL_
_®_
_ 2.5MG _
Perindopril arginine 2.5mg 
_COVERSYL_
_®_
_ 5MG _
Perindopril arginine 5mg 
_COVERSYL_
_®_
_ 10MG _
Perindopril arginine 10mg 

DESCRIPTION 

COVERSYL is perindopril arginine which has the chemical name, L-arginine (2S, 3aS, 7aS) - 1 - N 
- [ (S) -1 - ethoxycarbonyl butyl ] - L - alanyl) perhydroindole-2 - carboxylate (code name S9490-6).  
Perindopril is a dipeptide monoacid monoester with a
perhydroindole group and no sulphydryl 
radical.  Perindopril arginine is a white powder, readily soluble
in purified water, slightly soluble in 
95% ethanol and practically insoluble in chloroform.  Perindopril has five asymmetric centres.  The 
drug is synthesised stereoselectively so
that it is a single enantiomer (all S stereochemistry). 
_ _
_CAS Registry Number_:  612548-45-5 
_ _
_Molecular formula_:  C
19
H
32
N
2
O
5
, C
6
H
14
N
4
O
2

_Chemical structure_: 
,
N
H
H
COOH
O
N
H
CH
3
C
H
3
O
O
C
H
3
N
H
2
N
H
NH
COOH
NH
2

_Excipients: _
Lactose,  magnesium stearate, maltodextrin, silica -  colloidal anhydrous, sodium starch glycollate 
(type A), macrogol 6000.  All tablet coatings also include
glycerol, hypromellose and titanium 
dioxide. 

Specific to: 
·  COVERSYL 5MG - 
premix for light-green colour coating [copper chlorophyllin 
(E141ii)] 
·  COVERSYL 10MG - 
premix for green colour coating [copper chlorophyllin (E141ii)] 

COVERSYL
®
 (PERINDOPRIL ARGININE) – PRODUCT INFORMATION 

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PHARMACOLOGY 

MECHANISM OF ACTION 

Perindopril (prodrug), following hydrolysis to perindoprilat, inhibits angiotensin
converting enzyme 
(ACE) both in vitro and�