Land: Malaysia
Sprache: Englisch
Quelle: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
FLORFENICOL
Shennong Animal Health (Malaysia) Sdn. Bhd.
FLORFENICOL
1 kg
Shennong Animal Health (Malaysia) Sdn. Bhd.
SN-FLORFENICOL 5%W/W ORAL POWDER (FOR VETERINARY USE ONLY) COMPOSITION Florfenicol ……..……….………………………..………………......................... 50 mg/g PRODUCT DESCRIPTION The finished product is a white color powder. TARGET SPECIES Pigs (Fattening pigs) PHARMACODYNAMIC Florfenicol is a broad-spectrum synthetic antibiotic in the phenicol group that is active against most Gram-positive and Gram-negative bacteria isolated from domestic animals. Florfenicol acts by inhibition of protein synthesis at the ribosomal level and is bacteriostatic. PHARMACOKINETIC After administration to pigs by gavage at 10 mg/kg under experimental conditions, absorption of florfenicol was variable but peak serum concentrations of approximately 5µg/ml were reached approximately 3 hours after dosing. The terminal half-life was between 3 and 4 hours. When pigs were given free access, for 5 days, to feed medicated with florfenicol (premix for medicated feeding stuff) at the recommended dose of 10 mg/kg serum florfenicol concentrations exceeded 1 µg/ml for more than 16 hours each day of treatment. Florfenicol is well absorbed when administered orally and following distribution it is rapidly eliminated in the urine and faeces in a ration of 3:1. A fraction is excreted unchanged and the rest is metabolised into 5 major metabolites. INDICATIONS In fattening pigs: For the treatment and prevention of swine respiratory disease in infected herds due to _ Pasteurella multocida_ susceptible to florfenicol. The presence of the disease should be established in the herd before initiating preventive treatment. WARNINGS AND PRECAUTIONS 1. SPECIAL WARNINGS FOR EACH TARGET SPECIES: Animals showing a decreased appetite and/or a poor general condition should be treated by the parenteral route. 2. SPECIAL PRECAUTIONS FOR USE: I. SPECIAL PRECAUTIONS FOR USE IN ANIMALS: The product should be used in conjunction with susceptibility testing and take into account official and local policy relating to the use of antimicrobials. Use of Lesen Sie das vollständige Dokument