Држава: Малезија
Језик: Енглески
Извор: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
FLORFENICOL
Shennong Animal Health (Malaysia) Sdn. Bhd.
FLORFENICOL
1 kg
Shennong Animal Health (Malaysia) Sdn. Bhd.
SN-FLORFENICOL 5%W/W ORAL POWDER (FOR VETERINARY USE ONLY) COMPOSITION Florfenicol ……..……….………………………..………………......................... 50 mg/g PRODUCT DESCRIPTION The finished product is a white color powder. TARGET SPECIES Pigs (Fattening pigs) PHARMACODYNAMIC Florfenicol is a broad-spectrum synthetic antibiotic in the phenicol group that is active against most Gram-positive and Gram-negative bacteria isolated from domestic animals. Florfenicol acts by inhibition of protein synthesis at the ribosomal level and is bacteriostatic. PHARMACOKINETIC After administration to pigs by gavage at 10 mg/kg under experimental conditions, absorption of florfenicol was variable but peak serum concentrations of approximately 5µg/ml were reached approximately 3 hours after dosing. The terminal half-life was between 3 and 4 hours. When pigs were given free access, for 5 days, to feed medicated with florfenicol (premix for medicated feeding stuff) at the recommended dose of 10 mg/kg serum florfenicol concentrations exceeded 1 µg/ml for more than 16 hours each day of treatment. Florfenicol is well absorbed when administered orally and following distribution it is rapidly eliminated in the urine and faeces in a ration of 3:1. A fraction is excreted unchanged and the rest is metabolised into 5 major metabolites. INDICATIONS In fattening pigs: For the treatment and prevention of swine respiratory disease in infected herds due to _ Pasteurella multocida_ susceptible to florfenicol. The presence of the disease should be established in the herd before initiating preventive treatment. WARNINGS AND PRECAUTIONS 1. SPECIAL WARNINGS FOR EACH TARGET SPECIES: Animals showing a decreased appetite and/or a poor general condition should be treated by the parenteral route. 2. SPECIAL PRECAUTIONS FOR USE: I. SPECIAL PRECAUTIONS FOR USE IN ANIMALS: The product should be used in conjunction with susceptibility testing and take into account official and local policy relating to the use of antimicrobials. Use of Прочитајте комплетан документ