Adesan HCT

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Candesartan cilexetil; Hydrochlorothiazide

Available from:

Alphapharm Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

ADESAN
®
 HCT 16/12.5

_candesartan cilexetil 16 mg/hydrochlorothiazide 12.5 mg tablets_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers to some
common questions people ask about
Adesan HCT 16/12.5. It does not
contain all the information that is
known about Adesan HCT 16/12.5.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor will have
weighed the risks of you taking
Adesan HCT 16/12.5 against the
benefits they expect it will have for
you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THIS
MEDICINE.
You may need to read it again.
WHAT ADESAN HCT
16/12.5 IS USED FOR
Adesan HCT 16/12.5 is used to treat
high blood pressure.
Candesartan cilexetil is a type of
medicine called an angiotensin II -
receptor antagonist. It mainly works
by causing relaxation of blood
vessels.
Hydrochlorothiazide is a type of
medicine called a diuretic. It works
by reducing the amount of excess
fluid in the body.
Using these two medicines together
will lower your blood pressure more
than using either one on its own.
Your doctor will have explained why
you are being treated with Adesan
HCT 16/12.5 and told you what dose
to take.
FOLLOW ALL DIRECTIONS GIVEN TO YOU
BY YOUR DOCTOR CAREFULLY.
They may differ from the
information contained in this leaflet.
Your doctor may prescribe this
medicine for another use. Ask your
doctor if you want more information.
There is no evidence that Adesan
HCT 16/12.5 is addictive.
BEFORE YOU TAKE
[MEDICINE NAME]
_WHEN YOU MUST NOT TAKE IT_
DO NOT USE ADESAN HCT 16/12.5 IF
YOU HAVE AN ALLERGY TO:
•
any medicine containing
candesartan cilexetil, or
hydrochlorothiazide
•
any of the ingredients listed at the
end of this leaflet
•
any sulphur drugs
(sulphonamides) such as some
antibiotics or some medicines to
treat diabetes
SOME OF THE SYMPTOMS OF AN
ALLERGIC REACTION MAY INCLUDE:
•
shortness of breath
•
wheezing or difficulty breathin

Summary of Product characteristics

ADESAN
®
 HCT 16/12.5 
_Candesartan cilexetil 16 mg/ _
_Hydrochlorothiazide 12.5 mg tablets _
PRODUCT INFORMATION 
NAME OF THE MEDICINE 
The active ingredients in ADESAN HCT 16/12.5 are candesartan
cilexetil and hydrochlorothiazide. 
CANDESARTAN CILEXETIL:  
Chemical name: 
(±)-1-(cyclohexyloxycarbonyl-oxy) ethyl 2-ethoxy-1-[[2’-(1H-tetrazol-5-yl) biphenyl-
4-yl] methyl]-1H-benzimidazole-7- carboxylate 
Structural formula: 

Molecular Formula: C
33
H
34
N
6
O
6

Molecular Weight: 610.67 
CAS Registry No.: 145040-37-5 
HYDROCHLOROTHIAZIDE: 
Chemical name:  
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulphonamide 1,
1-dioxide 
Structural formula: 

Molecular Formula: C
7
H
8
N
3
S
2
O
4
Cl 
Molecular Weight: 297.7 
CAS Registry No.: 58-93-5 
DESCRIPTION 
Candesartan cilexetil a white to off white powder and is
practically insoluble in water. 
Hydrochlorothiazide  is  a  sulfonamide  derived  drug.    It  is  a  white,  or  almost  white  crystalline  powder  and  is 
very slightly soluble in water. 
In  addition  to  candesartan  cilexetil  and  hydrochlorothiazide,  ADESAN  HCT  16/12.5  tablets  also  contain 
lactose,  carmellose  calcium,  glyceryl  monosterate,  hydroxypropylcellulose,  iron  oxide  yellow  CI77492,  iron 
oxide red CI77491, starch – maize and magnesium stearate. 
ADESAN HCT 16/12.5 
– Product Information

2 

PHARMACOLOGY 
Angiotensin  II  is  the  primary  vasoactive  hormone  of  the  renin-angiotensinaldosterone  system  and  plays  a 
significant  role  in  the  pathophysiology  of  hypertension  and  other  cardiovascular  disorders.    It  also  has  an 
important role in the pathogenesis of end organ hypertrophy and damage.  The major physiological effects of 
angiotensin II, such as vasoconstriction, aldosterone stimulat