País: Austrália
Língua: inglês
Origem: Department of Health (Therapeutic Goods Administration)
Candesartan cilexetil; Hydrochlorothiazide
Alphapharm Pty Ltd
Medicine Registered
ADESAN ® HCT 16/12.5 _candesartan cilexetil 16 mg/hydrochlorothiazide 12.5 mg tablets_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers to some common questions people ask about Adesan HCT 16/12.5. It does not contain all the information that is known about Adesan HCT 16/12.5. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor will have weighed the risks of you taking Adesan HCT 16/12.5 against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THIS MEDICINE. You may need to read it again. WHAT ADESAN HCT 16/12.5 IS USED FOR Adesan HCT 16/12.5 is used to treat high blood pressure. Candesartan cilexetil is a type of medicine called an angiotensin II - receptor antagonist. It mainly works by causing relaxation of blood vessels. Hydrochlorothiazide is a type of medicine called a diuretic. It works by reducing the amount of excess fluid in the body. Using these two medicines together will lower your blood pressure more than using either one on its own. Your doctor will have explained why you are being treated with Adesan HCT 16/12.5 and told you what dose to take. FOLLOW ALL DIRECTIONS GIVEN TO YOU BY YOUR DOCTOR CAREFULLY. They may differ from the information contained in this leaflet. Your doctor may prescribe this medicine for another use. Ask your doctor if you want more information. There is no evidence that Adesan HCT 16/12.5 is addictive. BEFORE YOU TAKE [MEDICINE NAME] _WHEN YOU MUST NOT TAKE IT_ DO NOT USE ADESAN HCT 16/12.5 IF YOU HAVE AN ALLERGY TO: • any medicine containing candesartan cilexetil, or hydrochlorothiazide • any of the ingredients listed at the end of this leaflet • any sulphur drugs (sulphonamides) such as some antibiotics or some medicines to treat diabetes SOME OF THE SYMPTOMS OF AN ALLERGIC REACTION MAY INCLUDE: • shortness of breath • wheezing or difficulty breathin Leia o documento completo
ADESAN ® HCT 16/12.5 _Candesartan cilexetil 16 mg/ _ _Hydrochlorothiazide 12.5 mg tablets _ PRODUCT INFORMATION NAME OF THE MEDICINE The active ingredients in ADESAN HCT 16/12.5 are candesartan cilexetil and hydrochlorothiazide. CANDESARTAN CILEXETIL: Chemical name: (±)-1-(cyclohexyloxycarbonyl-oxy) ethyl 2-ethoxy-1-[[2’-(1H-tetrazol-5-yl) biphenyl- 4-yl] methyl]-1H-benzimidazole-7- carboxylate Structural formula: Molecular Formula: C 33 H 34 N 6 O 6 Molecular Weight: 610.67 CAS Registry No.: 145040-37-5 HYDROCHLOROTHIAZIDE: Chemical name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulphonamide 1, 1-dioxide Structural formula: Molecular Formula: C 7 H 8 N 3 S 2 O 4 Cl Molecular Weight: 297.7 CAS Registry No.: 58-93-5 DESCRIPTION Candesartan cilexetil a white to off white powder and is practically insoluble in water. Hydrochlorothiazide is a sulfonamide derived drug. It is a white, or almost white crystalline powder and is very slightly soluble in water. In addition to candesartan cilexetil and hydrochlorothiazide, ADESAN HCT 16/12.5 tablets also contain lactose, carmellose calcium, glyceryl monosterate, hydroxypropylcellulose, iron oxide yellow CI77492, iron oxide red CI77491, starch – maize and magnesium stearate. ADESAN HCT 16/12.5 – Product Information 2 PHARMACOLOGY Angiotensin II is the primary vasoactive hormone of the renin-angiotensinaldosterone system and plays a significant role in the pathophysiology of hypertension and other cardiovascular disorders. It also has an important role in the pathogenesis of end organ hypertrophy and damage. The major physiological effects of angiotensin II, such as vasoconstriction, aldosterone stimulat Leia o documento completo