Chemmart Gliclazide

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Gliclazide

Available from:

Apotex Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

CHEMMART GLICLAZIDE
TABLETS

_Contains the active ingredient gliclazide_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
This leaflet answers some common
questions about gliclazide. It does not
contain all the available information.
It does not take the place of talking to
your doctor, pharmacist or diabetes
educator.
The information in this leaflet was
last updated on the date listed on the
last page. More recent information on
this medicine may be available.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information.
You can also download the most up
to date leaflet from
www.apotex.com.au.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
Keep this leaflet with your medicine.
You may want to read it again.
WHAT THIS MEDICINE IS
USED FOR
The name of your medicine is
Chemmart Gliclazide. It contains the
active ingredient gliclazide.
It is used to:
•
control blood glucose (sugar) in
patients with Type II diabetes
mellitus.
This type of diabetes is also known
as non-insulin-dependent diabetes
mellitus (NIDDM) or maturity onset
diabetes.
Gliclazide is used when diet and
exercise are not enough to control
your blood glucose.
Gliclazide can be used alone or
together with other medicines for
treating diabetes
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you. Your
doctor may have prescribed this
medicine for another reason.
This medicine is available only with
a doctor's prescription.
_HOW IT WORKS_
Gliclazide belongs to a group of
medicines called the sulfonylureas.
Gliclazide lowers high blood glucose
by increasing the amount of insulin
produced by your pancreas.
Glucose is use

Summary of Product characteristics

Product Information 
– Australia 
Chemmart Gliclazide Tablets 
Page 1 
CHEMMART GLICLAZIDE TABLETS 

NAME OF THE MEDICINE 
Gliclazide 

Chemical Name:   

1-(3-azabicyclo[3.3.0]oct-3-yl)-3-_p_-tolylsulphonylurea. 

Structural Formula: 

Molecular Formula: 

C
15
H
21
N
3
O
3
S 

Molecular Weight:  

323.4 

CAS Registry Number:    
21187-98-4 

DESCRIPTION 
Gliclazide is a white or almost white powder which is practically insoluble in water.  

Gliclazide tablets are intended for oral administration. Each tablet contains gliclazide 80 mg. 

They  are  round,  white,  flat-sided  tablets  with  bevelled  e
dges,  engraved  “APO”  over  “80”  on  one  side, 
cross-scored on the other side.  

In  addition,  each  tablet  contains  the  following  inactive  ingredients:  croscarmellose  sodium, 
magnesium stearate,
colloidal anhydrous silica, lactose, microcrystalline cellulose
.  

PHARMACOLOGY 
PHARMACODYNAMICS 
Gliclazide  is  a  sulfonylurea  hypoglycaemic  agent  which  restores  the  diminished  first-phase  of  insulin 
secretion  noted  in  non-insulin  dependant  diabetes  mellitus.  Gliclazide  stimulates  insulin  secretion  from 
functional  pancreatic 

-cells  and  increases  the  sensitivity  of  the 

-cells  to  a  glucose  stimulus  (some 
residual 

-cell function is therefore necessary). 

Any  long-term  hypoglycaemic  activity  of  gliclazide  is  primarily  due  to  its  ability  to  maintain  an  effect  on 
insulin  secretion,  although  extrapancreatic  effects  may  also  be  involved.  Extrapancreatic  effects 
demonstrated for gliclazide include improvement in insulin mediated glucose utilisation and potentiation of 
postreceptor insulin sensiti