Country: Malaysia
Language: English
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ECONAZOLE NITRATE; TRIAMCINOLONE ACETONIDE
HOE PHARMACEUTICALS SDN. BHD.
ECONAZOLE NITRATE; TRIAMCINOLONE ACETONIDE
15 gm; 5 gm; 50 gm; 450 gm
HOE PHARMACEUTICALS SDN. BHD.
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ 1 ECOCORT CREAM Econazole Nitrate/ Triamcinolone Acetonide (1.0% w/w / 0.1%w/w) WHAT IS IN THIS LEAFLET 1. What ECOCORT CREAM is used for 2. How ECOCORT CREAM works 3. Before you use ECOCORT CREAM 4. How to use ECOCORT CREAM 5. While you are using ECOCORT CREAM 6. Side effects 7. Storage and Disposal of ECOCORT CREAM 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision This leaflet answers some common questions about ECOCORT CREAM. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. If you have any concerns about using this medicine, ask your doctor or pharmacist. Keep this leaflet with the medicine. You may want to read it again. WHAT ECOCORT CREAM IS USED FOR ECOCORT CREAM is used for treatment of fungal infections of the skin (problems with itching and irritation). HOW ECOCORT CREAM WORKS This medicine contains Econazole Nitrate, which has anti-fungal against a number of fungi causing infection to the skin and Triamcinolone Acetonide, a topically active corticosteroid which has potent anti- inflammatory, anti-itching and blood vessel narrowing actions. Ask your pharmacist or doctor if you have any questions about this medicine. BEFORE YOU USE ECOCORT CREAM _-When you must not take it _ _ _ Do not take ECOCORT CREAM if you are hypersensitive to any medicine containing Econazole Nitrate and Triamcinolone Acetonide or any of the ingredients listed at the end of this leaflet. _-Before you start to use it _ _ _ _Pregnancy and breast feeding_ : Ask your doctor or pharmacist for advice before taking any medicine. _-Taking other medicines _ _ _ Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. HOW TO USE ECOCOR Read the complete document
Est. 1979 ECOCORT CREAM Front Back NAME AND STRENGTH OF ACTIVE SUBSTANCE : Econazole Nitrate 1.0% w/w and Triamcinolone Acetonide 0.1% w/w. PRODUCT DESCRIPTION : A white cream. Other ingredients are Butylated Hydroxyanisole, Chlorocresol, Disodium Hydrogen Phosphate, Sodium Dihydrogen Phosphate, White Soft Paraffin, Cetomacrogol 1000, Propylene Glycol, Cetostearyl Alcohol, Liquid Paraffin, and Purified water. PHARMACODYNAMICS : Econazole nitrate is an imidazole anti-fungal agent closely related to miconazole and with similar antifungal and antibacterial activity. Ergosterol is important to the integrity and function of the fungal cell membrane. The imidazoles inhibit the incorporation of acetate into ergosterol, and they also inhibit lanosterol demethylase. There is disorganisation and thickening of the plasmalemma. The uptake of essential nutrient is impaired. Such mechanism would explain the selectivity for fungi and low toxicity for mammalian cells, but it does not explain the actions on gram-positive bacteria, anaerobes, and trichomonads. Minimum inhibitory concentrations range from 0.12 to 25 microgram per ml. It is two to eight times more active than miconazole against filamentous fungi, minimal inhibitory concentrations lie between 0.025 and 12.5 microgram per ml. Econazole is especially active against the mycelial forms. Triamcinolone acetonide is a topically active fluorinated corticosteroid which has anti-inflammatory, antipruritic and vasoconstrictive actions. PHARMACOKINETICS : Econazole Nitrate Econazole readily penetrates the stratum and is found in effective concentrations down to the mid-dermis. However, less that 1% of an applied dose appears to be absorbed into the blood. Following oral administration, about 40% of the dose is excreted in the urine and 30% is eliminated in faeces, in 5 days. A mean peak plasma concentration of 2.6 microgram per ml has been reported 2.5 hours after oral administration of 250mg of econazole to 8 subjects. Triamcinolone Acetonide Topical corticosteroids have anti-i Read the complete document