ECOCORT CREAM

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ECONAZOLE NITRATE; TRIAMCINOLONE ACETONIDE

Boleh didapati daripada:

HOE PHARMACEUTICALS SDN. BHD.

INN (Nama Antarabangsa):

ECONAZOLE NITRATE; TRIAMCINOLONE ACETONIDE

Unit dalam pakej:

15 gm; 5 gm; 50 gm; 450 gm

Dikeluarkan oleh:

HOE PHARMACEUTICALS SDN. BHD.

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
1
ECOCORT CREAM
Econazole Nitrate/ Triamcinolone Acetonide (1.0% w/w / 0.1%w/w)
WHAT IS IN THIS LEAFLET
1.
What ECOCORT CREAM is
used for
2.
How ECOCORT CREAM
works
3.
Before you use ECOCORT
CREAM
4.
How to use ECOCORT
CREAM
5.
While you are using
ECOCORT CREAM
6.
Side effects
7.
Storage and Disposal of
ECOCORT CREAM
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
This leaflet answers some common
questions
about
ECOCORT
CREAM. It does not contain all the
available information. It does not
take the place of talking to your
doctor or pharmacist.
All
medicines
have
risks
and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
If
you
have
any
concerns
about
using this medicine, ask your doctor
or pharmacist.
Keep this leaflet with the medicine.
You may want to read it again.
WHAT ECOCORT CREAM IS
USED FOR
ECOCORT
CREAM
is used for
treatment of fungal infections of the
skin
(problems
with
itching
and
irritation).
HOW ECOCORT CREAM
WORKS
This medicine contains Econazole
Nitrate,
which
has
anti-fungal
against a number of fungi causing
infection
to
the
skin
and
Triamcinolone
Acetonide,
a
topically
active
corticosteroid
which
has
potent
anti-
inflammatory,
anti-itching
and
blood vessel narrowing actions.
Ask your pharmacist or doctor if
you have any questions about this
medicine.
BEFORE YOU USE ECOCORT
CREAM
_-When you must not take it _
_ _
Do not take ECOCORT CREAM if
you
are
hypersensitive
to
any
medicine
containing
Econazole
Nitrate
and
Triamcinolone
Acetonide or any of the ingredients
listed at the end of this leaflet.
_-Before you start to use it _
_ _
_Pregnancy and breast feeding_
:
Ask your doctor or pharmacist for
advice before taking any medicine.
_-Taking other medicines _
_ _
Please
tell
your
doctor
or
pharmacist if you are taking or have
recently taken any other medicines,
including
medicines
obtained
without a prescription.
HOW TO USE ECOCOR

Ciri produk

Est. 1979
ECOCORT CREAM
Front
Back
NAME AND STRENGTH OF ACTIVE SUBSTANCE : Econazole Nitrate 1.0% w/w and
Triamcinolone Acetonide 0.1% w/w.
PRODUCT DESCRIPTION : A white cream.
Other ingredients are Butylated Hydroxyanisole, Chlorocresol, Disodium
Hydrogen Phosphate,
Sodium Dihydrogen Phosphate, White Soft Paraffin, Cetomacrogol 1000,
Propylene Glycol,
Cetostearyl Alcohol, Liquid Paraffin, and Purified water.
PHARMACODYNAMICS : Econazole nitrate is an imidazole anti-fungal agent
closely related to
miconazole and with similar antifungal and antibacterial activity.
Ergosterol is important to the
integrity and function of the fungal cell membrane. The imidazoles
inhibit the incorporation of
acetate into ergosterol, and they also inhibit lanosterol demethylase.
There is disorganisation
and thickening of the plasmalemma. The uptake of essential nutrient is
impaired. Such
mechanism would explain the selectivity for fungi and low toxicity for
mammalian cells, but it does
not explain the actions on gram-positive bacteria, anaerobes, and
trichomonads. Minimum
inhibitory concentrations range from 0.12 to 25 microgram per ml. It
is two to eight times more
active than miconazole against filamentous fungi, minimal inhibitory
concentrations lie between
0.025 and 12.5 microgram per ml. Econazole is especially active
against the mycelial forms.
Triamcinolone
acetonide
is
a
topically
active
fluorinated
corticosteroid
which
has
anti-inflammatory, antipruritic and vasoconstrictive actions.
PHARMACOKINETICS : Econazole Nitrate Econazole readily penetrates the
stratum and is
found in effective concentrations down to the mid-dermis. However,
less that 1% of an applied
dose appears to be absorbed into the blood. Following oral
administration, about 40% of the
dose is excreted in the urine and 30% is eliminated in faeces, in 5
days. A mean peak plasma
concentration of 2.6 microgram per ml has been reported 2.5 hours
after oral administration of
250mg of econazole to 8 subjects. Triamcinolone Acetonide Topical
corticosteroids have
anti-i