MOXICLAV DUO FORTE 875/125 amoxicillin trihydrate 875mg and clavulanic acid 125mg tablet blister pack

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

amoxicillin trihydrate,potassium clavulanate

Available from:

Southern Cross Pharma Pty Ltd

INN (International Name):

amoxicillin trihydrate,potassium clavulanate

Authorization status:

Registered

Patient Information leaflet

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MOXICLAV DUO 500/125 AND MOXICLAV DUO FORTE 875/125
[AMOXICILLIN TRIHYDRATE AND POTASSIUM CLAVULANATE]
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common questions about this medicine.
It does not contain all the available information. It does not take
the place of talking to your
doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the
risks of you being given this
medication against the benefits it is expected to have for you.
If you have any concerns about being given this medicine, ask your
doctor or pharmacist.
Keep this leaflet. You may need to read it again.
WHAT MOXICLAV DUO 500/125 AND MOXICLAV DUO FORTE 875/125 ARE USED FOR
Moxiclav Duo 500/125 and Moxiclav Duo Forte 875/125 tablets contain
two active ingredients.
One of these is from the penicillin group of antibiotics and is called
amoxicillin (from amoxicillin
trihydrate) and the other is clavulanic acid (from potassium
clavulanate). Moxiclav Duo 500/125
and Moxiclav Duo Forte 875/125 tablets are used to treat a wide range
of infections caused by
bacteria. These infections may affect the chest (bronchitis or
pneumonia), bladder (cystitis),
sinuses (sinusitis), the ears (otitis media) or the skin. Moxiclav Duo
500/125 and Moxiclav Duo
Forte 875/125 tablets work by killing the bacteria that cause these
infections. Moxiclav Duo
500/125 and Moxiclav Duo Forte 875/125 tablets will not work against
infections caused by
viruses such as colds or the flu. Your doctor may prescribe Moxiclav
Duo 500/125 and Moxiclav
Duo Forte 875/125 tablets for another use. If you want more
information ask your doctor. There
is no evidence that Moxiclav Duo 500/125 and Moxiclav Duo Forte
875/125 tablets are addictive.
BEFORE TAKING MOXICLAV DUO 500/125 AND MOXICLAV DUO FORTE 875/125 FOR
THE
FIRST TIME
_Do not take Moxiclav Duo 500/125 and Moxiclav Duo Forte 875/125
tablets if: _
_ _
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
you hav

Summary of Product characteristics

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PRODUCT INFORMATION
MOXICLAV DUO 500/125 AND MOXICLAV DUO FORTE 875/125
NAME OF THE MEDICINE
PROPRIETARY NAMES:
MOXICLAV DUO 500/125
tablets; and
MOXICLAV DUO FORTE 875/125
tablets
NON PROPRIETARY NAME:
Co-amoxiclav tablets
CHEMICAL NAMES:_ _
Amoxicillin trihydrate:
(2
_S_
,5
_R_
,6
_R_
)-6-[(
_R_
)-(-)-2-Amino-2-(
_p_
–hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-
azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate.
Potassium clavulanate:
Potassium (
_Z_
)-(2
_R_
,5
_R_
)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]-heptane-2-
carboxylate.
MOLECULAR FORMULA AND MOLECULAR WEIGHT:
Amoxicillin trihydrate – the molecular formula is C
16
H
19
N
3
O
5
S
ּ
◌3H
2
O, and
the molecular weight is 419.46.
Potassium clavulanate – the molecular formula is C
8
H
8
KNO
5
, and
the molecular weight is 237.25.
STRUCTURES:
_ _
The chemical structure of amoxicillin trihydrate is:
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The chemical structure of potassium clavulanate is:
CAS NUMBERS:
Amoxicillin trihydrate - 61336-70-7, and
Potassium clavulanate - 61177-45-5
_ _
DESCRIPTION
Amoxicillin is a semi-synthetic antibiotic.
Amoxicillin trihydrate is a white to off white crystalline powder and
is slightly soluble in
water.
Clavulanic acid is an irreversible inhibitor of many beta-lactamase
enzymes except type 1
(Richmond). It is a beta-lactam compound with only weak antibacterial
activity in its own
right.
Potassium clavulanate is a white to off white hygroscopic crystalline
powder and is freely
soluble in water.
Moxiclav Duo 500/125 is an immediate release tablet form and each
tablet contains
amoxycillin trihydrate equivalent to 500 mg amoxicillin and potassium
clavulanate equivalent
to 125 mg clavulanic acid.
Moxiclav Duo Forte 875/125 is an immediate release tablet form and
each tablet contains
amoxycillin trihydrate equivalent to 875 mg amoxicillin and potassium
clavulanate equivalent
to 125 mg clavulanic acid.
_ _
The excipients cont