Country: Malaysia
Language: English
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
PROCHLORPERAZINE MALEATE
SUNWARD PHARMACEUTICAL SDN. BHD.
PROCHLORPERAZINE MALEATE
1000 Tablets; 1000Tablet Tablets; 500 Tablet Tablets; 100 Tablet Tablets
SUNWARD PHARMACEUTICAL SDN. BHD.
PROPERAZINE TABLET Prochlorperazine Maleate (5mg) 1 _ CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET 1. What Properazine Tablet is used for 2. How Properazine Tablet works 3. Before you use Properazine Tablet 4. How to Use Properazine Tablet 5. While you are using it 6. Side effects 7. Storage and disposal of Properazine Tablet 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT PROPERAZINE TABLET IS USED FOR Properazine Tablet is used for control of severe nausea and vomiting and treatment of non-psychotic anxiety. HOW PROPERAZINE TABLET WORKS The active ingredient in the medicine is prochlorperazine maleate. Prochlorperazine maleate works by correcting chemical imbalances in the brain that causes nausea, vomiting and anxiety. BEFORE YOU USE PROPERAZINE TABLET _- When you must not use it _ Do not take this medicine if you: are hypersensitive to prochlorperazine maleate, or any other ingredients of this medicine (listed in Product Description). have bone marrow depression. have depression Do not use for children under 2 years of age or under 9kg in weight as safety has not been established. _- Before you start to use it _ Tell your doctor if you have: Reye's syndrome and other illness affecting the brain. glaucoma (increased pressure in eyes). exposed to extreme heat. surgery recently. intestinal obstruction. _Pregnancy and lactation _ Please consult your doctor or pharmacist if you are pregnant, planning for pregnancy or breast-feeding before using any medicine. Do not take this medicine if you are pregnant or breastfeeding as the medicine may be secreted into the breast milk and cause side effects in infants. Side effects such as jaundice, agitation, muscle spasm, tremor seen in new born whose mothers received prochlorperazine maleate. _- Taking other medicines _ Tell your doctor if you are taking:- medicine for cancer treatment. blood thinning agent. medicines to treat high blood pressure called t Read the complete document
Each tablet contains:- Prochlorperazine Maleate 5 mg PHARMACOLOGY: Prochlorperazine has a wide range of activity arising from its depressant actions on the central nervous system and its alpha-adrenergic blocking and weaker anti-cholinergic activities. It is a dopamine inhibitor, it inhibits prolactin-release inhibitory factor, considered to be dopamine, thus stimulating the release of prolactin. The turnover of dopamine in the brain is also increased. Prochlorperazine possesses sedative and tranquilising properties but patients usually develop tolerance rapidly to the sedation. It has anti-emetic, anti-pruritic and weak anti-histamine properties and inhibit the heat regulating centre so that the patient tends to acquire the temperature of his surroundings. Prochlorperazine produces direct effects on the heart and blood vessels and also indirect ones through actions on CNS and autonomic reflexes. Hypotension is primarily due to inhibition of centrally mediated pressor effects but peripheral alpha-adrenergic blockage may also play a role. There is also a direct depressant action on the heart. The drug has a vasodilating action due to both its effects on the autonomic nervous system and a direct action on blood vessels. PHARMACOKINETICS: Prochlorperazine is well absorbed from the gastrointestinal tract. From 60 to 70% of an administered dose is rapidly removed from the portal circulation by the liver and there is a very active enterohepatic circulation. Fecal excretion of prochlorperazine is significant. A reciprocal relationship exists between the amounts exc reted in the faeces and the urine.After absorption, it is rapidly distributed in all body tissues.Brain concentrations are relatively low compared to those in other organs, but considerably higher than in plasma; the highest concentrations of the drug is found in the lung, followed by the liver, the adrenal gland, and the spleen. INDICATIONS: For control of severe nausea and vomiting and treatment of non-psychotic anxiety. CONTRAINDICATIONS: It is contraindic Read the complete document