PROPERAZINE TABLET 5MG

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

PROCHLORPERAZINE MALEATE

Boleh didapati daripada:

SUNWARD PHARMACEUTICAL SDN. BHD.

INN (Nama Antarabangsa):

PROCHLORPERAZINE MALEATE

Unit dalam pakej:

1000 Tablets; 1000Tablet Tablets; 500 Tablet Tablets; 100 Tablet Tablets

Dikeluarkan oleh:

SUNWARD PHARMACEUTICAL SDN. BHD.

Risalah maklumat

PROPERAZINE TABLET
Prochlorperazine Maleate (5mg)
1
_ CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET
1. What Properazine Tablet is used for
2. How Properazine Tablet works
3. Before you use Properazine Tablet
4. How to Use Properazine Tablet
5. While you are using it
6. Side effects
7. Storage and disposal of Properazine Tablet
8. Product description
9. Manufacturer and Product Registration
Holder
10. Date of revision
WHAT PROPERAZINE TABLET IS USED FOR
Properazine
Tablet
is
used
for
control
of
severe nausea and vomiting and treatment of
non-psychotic anxiety.
HOW PROPERAZINE TABLET WORKS
The active
ingredient
in the medicine is
prochlorperazine
maleate. Prochlorperazine
maleate
works
by
correcting
chemical
imbalances in the brain that causes nausea,
vomiting and anxiety.
BEFORE YOU USE PROPERAZINE TABLET
_- When you must not use it _
Do not take this medicine if you:

are
hypersensitive
to
prochlorperazine
maleate, or any other ingredients of this
medicine (listed in Product Description).

have bone marrow depression.

have depression
Do not use for children under 2 years of age
or under 9kg in weight as safety has not been
established.
_- Before you start to use it _
Tell your doctor if you have:

Reye's syndrome and other illness affecting
the brain.

glaucoma (increased pressure in eyes).

exposed to extreme heat.

surgery recently.

intestinal obstruction.
_Pregnancy and lactation _
Please consult your doctor or pharmacist if
you are pregnant, planning for pregnancy or
breast-feeding before using any medicine.
Do not take this medicine if you are pregnant
or
breastfeeding
as
the
medicine
may
be
secreted into the breast milk and cause side
effects in infants.
Side
effects
such
as
jaundice,
agitation,
muscle spasm, tremor seen in new born whose
mothers received prochlorperazine maleate.
_- Taking other medicines _
Tell your doctor if you are taking:-

medicine for cancer treatment.

blood thinning agent.

medicines to treat high blood pressure called
t

Ciri produk

Each tablet contains:-
Prochlorperazine Maleate 5 mg
PHARMACOLOGY:
Prochlorperazine has a wide range of activity arising from its
depressant actions on the central nervous system and its
alpha-adrenergic blocking and weaker anti-cholinergic activities. It
is a dopamine inhibitor, it inhibits prolactin-release
inhibitory factor, considered to be dopamine, thus stimulating the
release of prolactin. The turnover of dopamine in the
brain is also increased. Prochlorperazine possesses sedative and
tranquilising properties but patients usually develop
tolerance rapidly to the sedation. It has anti-emetic, anti-pruritic
and weak anti-histamine properties and inhibit the heat
regulating centre so that the patient tends to acquire the temperature
of his surroundings. Prochlorperazine produces
direct effects on the heart and blood vessels and also indirect ones
through actions on CNS and autonomic reflexes.
Hypotension is primarily due to inhibition of centrally mediated
pressor effects but peripheral alpha-adrenergic blockage
may also play a role. There is also a direct depressant action on the
heart. The drug has a vasodilating action due to both
its effects on the autonomic nervous system and a direct action on
blood vessels.
PHARMACOKINETICS:
Prochlorperazine is well absorbed from the gastrointestinal tract.
From 60 to 70% of an administered dose is rapidly
removed from the portal circulation by the liver and there is a very
active enterohepatic circulation. Fecal excretion of
prochlorperazine is significant. A reciprocal relationship exists
between the amounts exc
reted in the faeces and the
urine.After absorption, it is rapidly distributed in all body
tissues.Brain concentrations are relatively low compared to those
in other organs, but considerably higher than in plasma; the highest
concentrations of the drug is found in the lung,
followed by the liver, the adrenal gland, and the spleen.
INDICATIONS:
For control of severe nausea and vomiting and treatment of
non-psychotic anxiety.
CONTRAINDICATIONS:
It is contraindic