Reaptan

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Perindopril arginine; Amlodipine besylate

Available from:

Servier Laboratories (Australia) Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

REAPTAN
®

_5MG/5MG; 5MG/10MG; 10MG/5MG; 10MG/10MG_
_Perindopril/amlodipine [pronounced per-in-do-pril/ am-load-i-peen]_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about REAPTAN.
It does not contain all the available
information about this medicine.
Reading this leaflet does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking REAPTAN
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
YOU MAY NEED TO READ IT AGAIN.
WHAT REAPTAN IS
The name of your medicine is
REAPTAN.
The medicine contains the active
ingredient perindopril arginine.
Perindopril belongs to a group of
medicines called angiotensin
converting enzyme (ACE) inhibitors.
It also contains the active ingredient
amlodipine besylate. Amlodipine
belongs to a group of medicines
called calcium channel blockers.
Calcium channel blockers do not
change the amount of calcium in
your blood or bones.
REAPTAN has been prescribed for
you by your doctor to replace the
separate tablets of perindopril and
amlodipine you were taking.
One REAPTAN tablet replaces
separate tablets of perindopril and
amlodipine.
WHAT REAPTAN IS
USED FOR
You have been prescribed
REAPTAN if you have high blood
pressure, also known as
hypertension.
_WHY REAPTAN IS USED FOR_
_HIGH BLOOD PRESSURE_
Everyone has blood pressure. This
pressure helps get your blood all
around the body. Your blood
pressure may be different at different
times of the day, depending on how
busy or stressed you are.
You have high blood pressure when
your blood pressure stays higher than
is needed, even when you are calm or
relaxed.
There are usually no symptoms of
high blood pressure. The only way of
knowing that you have it is to have
your blood pressure checked on a
regular basis. If high blood pressure
is not treated it can lead to seriou

Summary of Product characteristics

REAPTAN
®
 (PERINDOPRIL ARGININE/AMLODIPINE BESYLATE) 
– PRODUCT INFORMATION 

1 (28) 

Version 3 
_ _

PRODUCT INFORMATION 

NAME OF THE MEDICINE 

_REAPTAN 5MG/5MG _
perindopril arginine 5 mg/amlodipine besylate
†
 5 mg  

_REAPTAN 5MG/10MG _
perindopril arginine 5 mg/amlodipine besylate


10 mg  

_REAPTAN 10MG/5MG _
perindopril arginine 10 mg/amlodipine besylate


5 mg  

_REAPTAN 10MG/10MG _
perindopril arginine 10 mg/amlodipine besylate


10 mg  

RELATED TO PERINDOPRIL 

CAS Registry Number_:  612548-45-5  _
_ _
_Molecular formula_:  C
19
H
32
N
2
O
5
, C
6
H
14
N
4
O
2

_Chemical structure_: 

,
N
H
H
COOH
O
N
H
CH
3
C
H
3
O
O
C
H
3
N
H
2
N
H
NH
COOH
NH
2

RELATED TO AMLODIPINE 

_CAS Registry Number_: 111470-99-6 

_Molecular formula_:  C
20
H
25
CIN
2
O
5
.C
6
H
6
O
3
S 

_Chemical structure_: 

REAPTAN
®
 (PERINDOPRIL ARGININE/AMLODIPINE BESYLATE) 
– PRODUCT INFORMATION 

2 (28) 

Version 3 

DESCRIPTION 

ACTIVE INGREDIENTS 

PERINDOPRIL  ARGININE  has  the  chemical  name,  L-arginine  (2S,  3aS,  7aS)  -  1  -  N  -  [  (S)  -1  - 
ethoxycarbonyl  butyl  ]  -  L  -  alanyl)  perhydroindole-2  -  carboxylate.  It  is  a  dipeptide  monoacid 
monoester with a perhydroindole group and no sulphydryl radical.  Perindopril arginine is a white 
powder, readily soluble in purified water, slightly soluble in 95% ethanol and practically insoluble in 
chloroform.  Perindopril has five asymmetric centres.  The drug is synthesised stereoselectively so 
that it is a single enantiomer (all S stereochemistry). 

AMLODIPINE BESYLATE is a dihydropyridine derivative, and has the following chemical name: 3-ethyl 
5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-
pyridinedicarboxylate  benzene