Negara: Australia
Bahasa: Inggris
Sumber: Department of Health (Therapeutic Goods Administration)
atenolol
Generic Health Pty Ltd
Atenolol
Registered
Atenolol GH CMI v3 Aug17 Page 1 of 6 CONSUMER MEDICINE INFORMATION ATENOLOL GH atenolol What is in this leaflet This leaflet answers some common questions about Atenolol GH. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking Atenolol GH against the benefits they expect it will have for you. This medicine may also be used in emergency situations where you may be unconscious. In this case, this leaflet may be given to you after the medicine has been used. If you have any concerns about taking this medicine, ask your doctor or pharmacist. Keep this leaflet with the medicine. You may need to read it again. What Atenolol GH is used for Atenolol GH belongs to a group of medicines called beta-blockers. It works by affecting the body's response to certain nerve impulses, especially in the heart. As a result, it decreases the heart's need for blood and oxygen and therefore reduces the amount of work the heart has to do. It widens the blood vessels in the body, causing blood pressure to fall. It also helps the heart to beat more regularly. Atenolol GH is used to: lower high blood pressure, which is called hypertension prevent angina treat irregular heart rhythm or beat called arrhythmias treat heart attacks, or reduce your risk of heart complications following a heart attack Atenolol GH may be either used alone or in combination with other medicines to treat your condition. Atenolol GH may also be used in emergency situations or during surgery to treat a fast heart beat before, during or after surgery. Hypertension Everyone has blood pressure. This pressure helps to push blood all around your body. Your blood pressure changes during the day, depending on how busy you are or how you are feeling. You have hypertension (high blood pressure) when your blood pressure stays higher than is needed, even when you are calm and relaxed. Regular blood pressure checks Baca dokumen lengkapnya
PI Atenolol GH v1 121024 1 of 11 PRODUCT INFORMATION ATENOLOL GH Atenolol tablets NAME OF THE MEDICINE Atenolol. CHEMICAL NAME: 2-[4-[(2_RS_)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl] acetamide. MOLECULAR FORMULA: C 14 H 22 N 2 O 3 MOLECULAR WEIGHT: 266.3 g/mol CAS REGISTRY NO.: 29122-68-7 DESCRIPTION Atenolol is white to almost white powder. It is sparingly soluble in water, soluble in ethanol, slightly soluble in methylene chloride. Atenolol GH is available as tablets containing 50 mg atenolol. Atenolol GH tablets contain the following inactive ingredients: starch-maize, gelatin, magnesium carbonate- heavy, magnesium stearate and sodium lauryl sulfate PHARMACOLOGY Atenolol is a beta-adrenoreceptor blocking drugs which acts preferentially on beta-receptors in the heart. Selectivity decreases with increasing dose. It has little intrinsic sympathomimetic activity and no membrane stabilising activity. Atenolol is a racemic mixture and its activity resides in the S(-) enantiomer. It reduces raised blood pressure by an unknown mechanism, and also inhibits exercise-induced tachycardia and decreases plasma renin concentration. It causes slight airways obstruction but less than that seen with nonselective beta-blockers. The inhibition of exercise-induced tachycardia is correlated with blood levels but there is no correlation between plasma concentrations and antihypertensive effect. Atenolol is effective and well tolerated in most ethnic populations although the response may be less in Afro-Caribbean black patients. The possible mechanism of the anti-anginal activity of atenolol appears to be due to a reduction in left ventricular work and oxygen utilisation resulting (mainly) from the decrease in heart rate and contractility. N H 2 O O N H CH 3 CH 3 OH and enantiomer PI Atenolol GH v1 121024 2 of 11 The antiarrhythmic effect of atenolol is apparently due to its antisympathetic effect. There is no evidence that membrane stabilising activity or intrinsic sympathomimetic activity are necessary for antiarrhythmic e Baca dokumen lengkapnya