情報リーフレット
Ciproxin HC CMI
1
CIPROXIN
®
HC EAR DROPS
_Ciprofloxacin & Hydrocortisone _
_ _
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY
BEFORE YOU START TO USE
CIPROXIN HC EAR DROPS.
This leaflet has been written to
answer some common
questions about CIPROXIN HC
Ear Drops. It does not contain
all of the available information
and does not take the place of
talking to your doctor or
pharmacist.
All medicines have risks and
benefits. In deciding to
prescribe CIPROXIN HC Ear
Drops for you or your child, your
doctor has weighed the potential
risks and benefits of using this
medicine.
The information in this leaflet
applies to CIPROXIN HC Ear
Drops only. This information
does not apply to similar
products, even if they contain
the same ingredients.
IF YOU HAVE ANY CONCERNS
ABOUT USING CIPROXIN HC EAR
DROPS, ASK YOUR DOCTOR OR
PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need it
again.
WHAT CIPROXIN HC
EAR DROPS IS USED FOR
CIPROXIN HC Ear Drops
contains two active ingredients:
CIPROFLOXACIN
; a
“fluoroquinolone” antibiotic,
which kills the bacteria
causing the infection.
HYDROCORTISONE
; a
corticosteroid, that reduces
the pain, redness and/or
inflammation.
CIPROXIN HC Ear Drops is
used to treat bacterial otitis
externa, which is an infection of
the outer ear caused by bacteria
and may cause itching or pain.
Before prescribing CIPROXIN
HC Ear Drops for you or your
child, your doctor will have
examined the ear and decided
that CIPROXIN HC Ear Drops is
the right medicine.
Your doctor may have
prescribed CIPROXIN HC Ear
drops for another reason. Ask
your doct
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製品の特徴
Ciproxin-HC (130112)
1
CIPROXIN
®
HC EAR DROPS
(CIPROFLOXACIN & HYDROCORTISONE)
PRODUCT INFORMATION
NAME OF THE DRUG
Active ingredients (INN):
ciprofloxacin hydrochloride (CAS 86393-32-0)
hydrocortisone (CAS 50-23-7).
DESCRIPTION
Ciprofloxacin hydrochloride
A synthetic carboxyquinolone derivative with broad spectrum antimicrobial activity. It is the
monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-
piperazinyl)-3-quinolinecarboxylic acid. It is a faintly yellowish to yellow crystalline substance
with a molecular weight of 385.8. Its empirical formula is C
17
H
18
FN
3
O
3
.HCl.H
2
O and its chemical
structure is as follows:
Hydrocortisone
A white to off-white crystalline powder, practically insoluble in water, sparingly soluble in acetone
and in alcohol, soluble in chloroform with a molecular weight of 362.47. It is an
anti-inflammatory corticosteroid, with a chemical name of 11ß, 17, 21-trihydroxypregn-4-ene-
3,20-dione, and its empirical formula is C
21
H
30
O
5
. Its chemical structure is as follows:
CIPROXIN HC Ear Drops contain benzyl alcohol as a preservative. Other excipients are:
polysorbate 20, sodium acetate, acetic acid-glacial, sodium chloride, hydrogenated soy
phosphatidylcholine, polyvinyl alcohol, water-purified.
COOH
F
HN
N
N
O
HCl
H
2
O
O
H
3
C
HO
H
H
CH
3
H
OH
CH
2
OH
O
Ciproxin-HC (130112)
2
PHARMACOLOGY
Ciprofloxacin has _in-vitro_ activity against a wide range of gram-negative and gram-positive
organisms. The bactericidal action of ciprofloxacin results from interference with the enzyme
DNA gyrase which is needed for the synthesis of bac
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