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TRANDATE- Consumer Medicine Information
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TRANDATE
TM
_LABETALOL HYDROCHLORIDE_
CONSUMER MEDICINE INFORMATION (CMI)
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about TRANDATE
tablets. It does not contain all the
available information. It does not
take the place of talking to your
doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking TRANDATE
against the benefits he or she expects
it will have.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE
MEDICINE.
You may need to read it again.
WHAT TRANDATE IS USED
FOR
The name of your medicine is
TRANDATE. The active ingredient
is called _labetalol hydrochloride_.
_Labetalol hydrochloride_ belongs to a
group of medicines called the beta-
blockers. The beta- blockers are
used for the treatment of high blood
pressure (hypertension).
TRANDATE is used for the
treatment of all degrees of
hypertension. Hypertension is a
condition marked by high blood
pressure.
TRANDATE is used to lower high
blood pressure. It works by changing
the body’s response to some nerve
impulses. Therefore, it widens the
blood vessels in the body, causing
the blood pressure to fall.
Your doctor may have prescribed
this medicine for another condition.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY TRANDATE
HAS BEEN PRESCRIBED FOR YOU.
TRANDATE tablets are only
available with a doctor’s
prescription.
BEFORE YOU TAKE IT
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE TRANDATE IF YOU
ARE ALLERGIC TO:
labetalol hydrochloride or any
other agents used to treat
hypertension
any of the ingredients listed at the
end of
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製品の特徴
TRANDATE- Product Information
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PRODUCT INFORMATION
APPROVED NAME:
Labetalol hydrochloride
TRADE NAME:
Trandate™
CHEMICAL FORMULA COMPOSITION:
Labetalol hydrochloride is a dry powder. The chemical name is: 2-hydroxy-5[1-hydroxy-2(1-
methyl-3-phenylpropyl amino) ethyl] benzamide hydrochloride.
PHARMACOLOGY:
Trandate antagonises alpha- and beta-adrenoceptors
concurrently by competitive inhibition; it
has no intrinsic sympathomimetic activity and less pronounced membrane stabilising activity
than propranolol. The beta-blockade is non-selective. Trandate has two centres of chirality
which means that four isomers are possible, each of the isomers having different relative
alpha- and beta-blocking activities.
MODE OF ACTION
Trandate lowers blood pressure by blocking alpha-adrenoceptors in peripheral arterioles and
thereby reducing peripheral resistance. Trandate also
concurrently blocks beta-adrenoceptors,
notably in the heart, from the reflexly mediated drive caused by the peripheral vasodilatation.
Therefore, the reduction in blood pressure is achieved without cardiac stimulation. Trandate
does not reduce cardiac output at rest, or after moderate exercise. Normally occurring
increases in systolic pressure during exercise are, however, lessened by Trandate;
corresponding changes in
the diastolic pressure are not affected.
The precise relationship between alpha- and beta-blocking effects in contributing to the
antihypertensive action is unknown. At therapeutic doses, Trandate is less active at alpha-
adrenoceptors than beta-adrenoceptors, and adequate vasodilatation is achieved with
incomplete blockade of the a
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