资料单张
INDICATIONS [/za_1143.html#1]
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CONTRA-INDICATIONS [/za_1143.html#1]
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DOSAGE [/za_1143.html#1]
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SIDE-EFFECTS [/za_1143.html#1]
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PREGNANCY [/za_1143.html#1]
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OVERDOSE [/za_1143.html#1]
IDENTIFICATION [/za_1143.html#1]
[/za_1143.html#1] PATIENT INFORMATION
GASTROGRAFIN
SCHEDULING STATUS:
S2
PROPRIETARY NAME
(and dosage form):
GASTROGRAFIN
AQUEOUS SOLUTION FOR ENTERAL USE
COMPOSITION
Gastrografin contains a mixture of
SODIUM AMIDOTRIZOATE
and
MEGLUMINE AMIDOTRIZOATE
in a proportion of 10:66
(amidotrizoic acid or diatrizoic acid: 3,5-bis-acetamido-2,4,6-triiodobenzoic acid).
1 mL Gastrografin contains sodium amidotrizoate 100,00 mg and meglumine amidotrizoate 660,00 mg (sodium
diatrizoate and meglumine diatrizoate) in aqueous solution plus flavourings and a wetting agent.
Iodine concentration
370 mg/mL
Iodine content per bottle of 100 mL
37 g
Contrast medium concentration
760 mg/mL
Contrast medium content per bottle of 100 mL 76 g
Viscosity (mPa.s or cP)
at 20°C
18,5
at 37°C
8,9
Osmotic pressure at 37°C
(MPa)
5,58
(atm)
55,1
Osmolality at 37°C (osm/kg H
2
O)
2,15
PHARMACOLOGICAL CLASSIFICATION
A. 28 Contrast media.
PHARMACOLOGICAL ACTION
ACTIONS
The contrast-giving substances in Gastrografin are salts of amidotrizoic acid in which the X-ray absorbing iodine is
present in stable chemical bond.
PHARMACOKINETICS
Following oral administration only about 3% of the amidotrizoic acid is absorbed from the stomach and intestines. This
portion, and also any contrast medium that might
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