Страна: Австралия
Език: английски
Източник: Department of Health (Therapeutic Goods Administration)
Ramipril
Aspen Pharma Pty Ltd
Medicine Registered
PRILACE - Consumer Medicine Information Page 1 of 5 PRILACE ramipril CONSUMER MEDICINE INFORMATION (CMI) WHAT IS IN THIS LEAFLET This leaflet answers some common questions about PRILACE. It does not contain all of the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking PRILACE against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, TALK TO YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH YOUR MEDICINE. You may need to read it again. WHAT PRILACE IS USED FOR PRILACE contains ramipril, which belongs to a group of medicines called angiotensin-converting enzyme (ACE) inhibitors. PRILACE is used to treat: high blood pressure (hypertension) some heart conditions such as heart failure after a heart attack kidney problems in some patients. PRILACE is also used to reduce the risk of cardiovascular problems and complications in patients aged 55 years or more with heart or blood vessel disease, or diabetes. HYPERTENSION PRILACE is used to lower high blood pressure (hypertension). Everyone has blood pressure. This pressure helps circulating your blood around your body. Your blood pressure is different at different times of the day and can be affected by how busy or worried you are. You would have hypertension when your blood pressure stays higher than is needed, even when you are calm and relaxed. There are usually no symptoms of hypertension. The only way of knowing you have hypertension is to have your blood pressure checked on a regular basis. If hypertension is not treated, it can lead to s Прочетете целия документ
PRILACE- Product Information Page 1 of 17 Prilace PRODUCT INFORMATION NAME OF THE DRUG Ramipril. The chemical name for ramipril is (2S,3aS,6aS)-1-[(S)-N-[(S)-1-carboxy)-3- phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid, 1-ethyl ester. Its structural formula is: C 23 H 32 N 2 O 5 Molecular weight: 416.5 CAS No.: 87333-19-5 Ramipril is a 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivative. It has five chiral centres with an S-configuration in all five asymmetric carbon atoms. DESCRIPTION Ramipril is a white to almost white, crystalline powder soluble in polar organic solvents and buffered aqueous solutions. Ramipril melts between 105 0 C and 112 0 C. Prilace tablets come in four strengths and contain 1.25 mg, 2.5 mg, 5 mg and 10 mg* of ramipril. The tablets also contain sodium bicarbonate, calcium sulfate, pregelatinised maize starch and sodium stearylfumarate. The tablets are gluten free. (*currently not marketed) Prilace capsules contain 10 mg of ramipril. The capsules also contain pregelatinised maize starch. The capsule shells are size #4 Hard Gelatin Capsules G41CSRR0238 White Op/Blue Op with black printing ink (TekPrint SW-9008 or SW-9009). The capsules are also gluten free. PHARMACOLOGY MECHANISM OF ACTION Ramipril is a prodrug which, after absorption from the gastrointestinal tract, is hydrolysed in the liver to form the active moiety, ramiprilat. Ramipril and ramiprilat inhibit angiotensin-converting enzyme (ACE) which is identical to kininase II. This converting enzyme (ACE) is a peptidyl dipeptidase that catalyses the conversion of angiotensi Прочетете целия документ