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PRILACE - Consumer Medicine Information
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PRILACE
ramipril
CONSUMER MEDICINE INFORMATION (CMI)
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about PRILACE.
It does not contain all of the
available information.
It does not take the place of talking
to your doctor or pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking PRILACE against
the benefits they expect it will have
for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO
YOUR DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT PRILACE IS USED
FOR
PRILACE contains ramipril, which
belongs to a group of medicines
called angiotensin-converting
enzyme (ACE) inhibitors.
PRILACE is used to treat:
high blood pressure
(hypertension)
some heart conditions such as
heart failure after a heart attack
kidney problems in some
patients.
PRILACE is also used to reduce the
risk of cardiovascular problems and
complications in patients aged 55
years or more with heart or blood
vessel disease, or diabetes.
HYPERTENSION
PRILACE is used to lower high blood
pressure (hypertension). Everyone
has blood pressure. This pressure
helps circulating your blood around
your body. Your blood pressure is
different at different times of the
day and can be affected by how
busy or worried you are. You
would have hypertension when your
blood pressure stays higher than is
needed, even when you are calm
and relaxed.
There are usually no symptoms of
hypertension. The only way of
knowing you have hypertension is
to have your blood pressure
checked on a regular basis. If
hypertension is not treated, it can
lead to s
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产品特点
PRILACE- Product Information
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Prilace
PRODUCT INFORMATION
NAME OF THE DRUG
Ramipril. The chemical name for ramipril is (2S,3aS,6aS)-1-[(S)-N-[(S)-1-carboxy)-3-
phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid, 1-ethyl ester. Its structural
formula is:
C
23
H
32
N
2
O
5
Molecular weight: 416.5
CAS No.: 87333-19-5
Ramipril is a 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivative. It has five chiral centres with
an S-configuration in all five asymmetric carbon atoms.
DESCRIPTION
Ramipril is a white to almost white,
crystalline powder soluble in
polar organic solvents and buffered
aqueous solutions. Ramipril melts between 105
0
C and 112
0
C.
Prilace tablets come in four strengths and contain 1.25 mg, 2.5 mg, 5 mg and 10 mg* of ramipril.
The tablets also contain sodium bicarbonate, calcium sulfate, pregelatinised maize starch and
sodium stearylfumarate. The tablets
are gluten free. (*currently not marketed)
Prilace capsules contain 10 mg of ramipril. The capsules also contain pregelatinised maize starch.
The capsule shells are size #4 Hard Gelatin Capsules G41CSRR0238 White Op/Blue Op with black
printing ink (TekPrint SW-9008 or SW-9009). The capsules
are also gluten free.
PHARMACOLOGY
MECHANISM OF ACTION
Ramipril is a prodrug which, after absorption from the gastrointestinal tract, is hydrolysed in the
liver to form the active moiety, ramiprilat. Ramipril and ramiprilat inhibit angiotensin-converting
enzyme (ACE) which is identical to kininase II. This converting enzyme (ACE) is a peptidyl
dipeptidase that catalyses the conversion of angiotensi
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